Abstract
Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.
| Original language | English |
|---|---|
| Article number | 290 |
| Journal | Frontiers in immunology |
| Volume | 11 |
| DOIs | |
| State | Published - Feb 21 2020 |
Keywords
- conventional NK cells
- maternal-fetal interface
- pregnancy
- tissue-resident NK cells
- uterine NK cells
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