TY - JOUR
T1 - Uterine Natural Killer Cell Heterogeneity
T2 - Lessons From Mouse Models
AU - Sojka, Dorothy K.
N1 - Publisher Copyright:
© Copyright © 2020 Sojka.
PY - 2020/2/21
Y1 - 2020/2/21
N2 - Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.
AB - Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.
KW - conventional NK cells
KW - maternal-fetal interface
KW - pregnancy
KW - tissue-resident NK cells
KW - uterine NK cells
UR - http://www.scopus.com/inward/record.url?scp=85081133531&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.00290
DO - 10.3389/fimmu.2020.00290
M3 - Review article
C2 - 32153593
AN - SCOPUS:85081133531
SN - 1664-3224
VL - 11
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 290
ER -