@article{20653d540dc4432faa83e4bc83b2b4a8,
title = "Uterine contractions in rodent models and humans",
abstract = "Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.",
keywords = "animal models, contraction, myometrium, parturition, pregnancy, species differences, uterus",
author = "Manasi Malik and Michelle Roh and England, {Sarah K.}",
note = "Funding Information: The writing of the original draft of this review was funded by Corteva Agriscience, which commissioned a white paper on species differences in uterine contractions. Manasi Malik is funded by the National Institute of Child Health and Human Development (F30 HD097925). Sarah K. England is funded by the National Institute of Child Health and Human Development (R01HD088097, R01HD096737, and R01HD037831) and the March of Dimes (#6-FY18-664). The authors thank Dr Deborah Frank for her invaluable assistance in editing this manuscript. Figures were designed with BioRender.com. Funding Information: The writing of the original draft of this review was funded by Corteva Agriscience, which commissioned a white paper on species differences in uterine contractions. Manasi Malik is funded by the National Institute of Child Health and Human Development (F30 HD097925). Sarah K. England is funded by the National Institute of Child Health and Human Development (R01HD088097, R01HD096737, and R01HD037831) and the March of Dimes (#6‐FY18‐664). The authors thank Dr Deborah Frank for her invaluable assistance in editing this manuscript. Figures were designed with BioRender.com. Publisher Copyright: {\textcopyright} 2020 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.",
year = "2021",
month = apr,
doi = "10.1111/apha.13607",
language = "English",
volume = "231",
journal = "Acta Physiologica",
issn = "1748-1708",
number = "4",
}