Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease

Parakkal Deepak; William J. Sandborn

doi:10.1016/j.gtc.2017.05.013

Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease

Parakkal Deepak, William J. Sandborn

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

This article reviews the available data regarding the efficacy of ustekinumab across published randomized clinical trials and open-label experience from tertiary medical centers, safety data, including in pregnancy, and its use in patients who have failed tumor necrosis factor (TNF) antagonists as well as patients who have not failed TNF antagonists. We have proposed an algorithm for positioning the use of ustekinumab among other agents (TNF antagonists, vedolizumab) in moderate-severe Crohn's disease. The article also enumerates drugs that are specific interleukin-23 blockers, including brazikumab (MEDI2070), risankizumab, LY3074828, tildrakizumab, and guselkumab, and the current status of their clinical trials.

Original language	English
Pages (from-to)	603-626
Number of pages	24
Journal	Gastroenterology Clinics of North America
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.gtc.2017.05.013
State	Published - Sep 2017

Keywords

Crohn's disease
Inflammatory bowel disease
Interleukin-12
Interleukin-12/23 monoclonal antibody
Interleukin-23
Ustekinumab

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10.1016/j.gtc.2017.05.013

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title = "Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease",

abstract = "This article reviews the available data regarding the efficacy of ustekinumab across published randomized clinical trials and open-label experience from tertiary medical centers, safety data, including in pregnancy, and its use in patients who have failed tumor necrosis factor (TNF) antagonists as well as patients who have not failed TNF antagonists. We have proposed an algorithm for positioning the use of ustekinumab among other agents (TNF antagonists, vedolizumab) in moderate-severe Crohn's disease. The article also enumerates drugs that are specific interleukin-23 blockers, including brazikumab (MEDI2070), risankizumab, LY3074828, tildrakizumab, and guselkumab, and the current status of their clinical trials.",

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AB - This article reviews the available data regarding the efficacy of ustekinumab across published randomized clinical trials and open-label experience from tertiary medical centers, safety data, including in pregnancy, and its use in patients who have failed tumor necrosis factor (TNF) antagonists as well as patients who have not failed TNF antagonists. We have proposed an algorithm for positioning the use of ustekinumab among other agents (TNF antagonists, vedolizumab) in moderate-severe Crohn's disease. The article also enumerates drugs that are specific interleukin-23 blockers, including brazikumab (MEDI2070), risankizumab, LY3074828, tildrakizumab, and guselkumab, and the current status of their clinical trials.

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Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease

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Keywords

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