@article{b7f04e4fb560460895ccf23adc58e173,
title = "Using the A/T/N framework to examine driving in preclinical Alzheimer's disease",
abstract = "The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5-10 years. Driving is a widespread functional activity that may be particularly useful in investigation of functional changes in pathological AD before onset of cognitive symptoms. We examined driving in preclinical AD using the A/T/N framework and found that the onset of driving difficulties is most associated with abnormality of both amyloid and tau pathology, rather than amyloid alone. These results have implications for participant selection into clinical trials and for the application time of interventions aimed at prolonging the time of safe driving among older adults with preclinical AD.",
keywords = "Alzheimer disease, Biomarkers, Cerebrospinal fluid, Dementia, Driving, Imaging, Preclinical Alzheimer disease",
author = "Roe, {Catherine M.} and Babulal, {Ganesh M.} and Stout, {Sarah H.} and Carr, {David B.} and Williams, {Monique M.} and Benzinger, {Tammie L.S.} and Fagan, {Anne M.} and Holtzman, {David M.} and Ances, {Beau M.} and Morris, {John C.}",
note = "Funding Information: This research was funded by the National Institute on Aging [NIA, R01AG043434, R01AG43434-03S1, R01AG056466, P50AG005681, P01AG003991, P01AG026276]; Fred Simmons and Olga Mohan, the Farrell Family Research Fund and the Charles and Joanne Knight Alzheimer's Research Initiative of the Washington University Knight Alzheimer Disease Research Center (ADRC).The authors thank the participants, investigators and staff of the Knight ADRC Clinical Core for participant assessments, Genetics Core for APOE genotyping, Biomarker Core for cerebrospinal fluid collection and analysis and the Imaging Core for amyloid imaging. Imaging facilities were supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). Imaging analyses used the services of the Neuroimaging Informatics and Analysis Center, supported by NIH grant 5P30NS048056. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = jun,
day = "1",
doi = "10.3390/geriatrics3020023",
language = "English",
volume = "3",
journal = "Geriatrics (Switzerland)",
issn = "2308-3417",
number = "2",
}