Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration

A. K. Knutsen; W. T. Wang; J. E. McEntee; J. Zhuo; R. Gullapalli; J. L. Prince; P. V. Bayly; J. B. Butman; D. L. Pham

doi:10.1007/978-1-4614-6351-1_15

Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration

A. K. Knutsen, W. T. Wang, J. E. McEntee, J. Zhuo, R. Gullapalli, J. L. Prince, P. V. Bayly, J. B. Butman, D. L. Pham

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

A quantitative three-dimensional (3D) description of the deformation of brain tissue during acceleration of the skull is necessary to provide understanding of the underlying mechanisms of traumatic brain injury. Tagged magnetic resonance imaging (MRI) allows for the noninvasive measurement of the deformation of biological tissue. In this study, tagged MRI with harmonic phase (HARP) analysis was used to quantify the 3D deformation during angular acceleration of a gelatin phantom and the head of a human cadaver specimen. Two-dimensional results from the gelatin phantom showed good agreement with previously published results. Two-dimensional strains in the cadaver brain were lower in magnitude than previously reported results from a similar experiment in the live human brain. Strains on the inferior–superior axis were measured and shown to be of similar magnitude to the strain components in the plane formed by the anterior–posterior and left–right axes. Future studies will involve the acquisition of 3D deformation fields in live humans and additional cadaver specimens.

Original language	English
Title of host publication	Computational Biomechanics for Medicine
Subtitle of host publication	Models, Algorithms and Implementation
Publisher	Springer New York
Pages	169-183
Number of pages	15
ISBN (Electronic)	9781461463511
ISBN (Print)	9781461463504
DOIs	https://doi.org/10.1007/978-1-4614-6351-1_15
State	Published - Jan 1 2013

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Knutsen, A. K., Wang, W. T., McEntee, J. E., Zhuo, J., Gullapalli, R., Prince, J. L., Bayly, P. V., Butman, J. B., & Pham, D. L. (2013). Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration. In Computational Biomechanics for Medicine: Models, Algorithms and Implementation (pp. 169-183). Springer New York. https://doi.org/10.1007/978-1-4614-6351-1_15

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title = "Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration",

abstract = "A quantitative three-dimensional (3D) description of the deformation of brain tissue during acceleration of the skull is necessary to provide understanding of the underlying mechanisms of traumatic brain injury. Tagged magnetic resonance imaging (MRI) allows for the noninvasive measurement of the deformation of biological tissue. In this study, tagged MRI with harmonic phase (HARP) analysis was used to quantify the 3D deformation during angular acceleration of a gelatin phantom and the head of a human cadaver specimen. Two-dimensional results from the gelatin phantom showed good agreement with previously published results. Two-dimensional strains in the cadaver brain were lower in magnitude than previously reported results from a similar experiment in the live human brain. Strains on the inferior–superior axis were measured and shown to be of similar magnitude to the strain components in the plane formed by the anterior–posterior and left–right axes. Future studies will involve the acquisition of 3D deformation fields in live humans and additional cadaver specimens.",

author = "Knutsen, {A. K.} and Wang, {W. T.} and McEntee, {J. E.} and J. Zhuo and R. Gullapalli and Prince, {J. L.} and Bayly, {P. V.} and Butman, {J. B.} and Pham, {D. L.}",

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Knutsen, AK, Wang, WT, McEntee, JE, Zhuo, J, Gullapalli, R, Prince, JL, Bayly, PV, Butman, JB & Pham, DL 2013, Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration. in Computational Biomechanics for Medicine: Models, Algorithms and Implementation. Springer New York, pp. 169-183. https://doi.org/10.1007/978-1-4614-6351-1_15

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AU - Knutsen, A. K.

AU - Wang, W. T.

AU - McEntee, J. E.

AU - Zhuo, J.

AU - Gullapalli, R.

AU - Prince, J. L.

AU - Bayly, P. V.

AU - Butman, J. B.

AU - Pham, D. L.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - A quantitative three-dimensional (3D) description of the deformation of brain tissue during acceleration of the skull is necessary to provide understanding of the underlying mechanisms of traumatic brain injury. Tagged magnetic resonance imaging (MRI) allows for the noninvasive measurement of the deformation of biological tissue. In this study, tagged MRI with harmonic phase (HARP) analysis was used to quantify the 3D deformation during angular acceleration of a gelatin phantom and the head of a human cadaver specimen. Two-dimensional results from the gelatin phantom showed good agreement with previously published results. Two-dimensional strains in the cadaver brain were lower in magnitude than previously reported results from a similar experiment in the live human brain. Strains on the inferior–superior axis were measured and shown to be of similar magnitude to the strain components in the plane formed by the anterior–posterior and left–right axes. Future studies will involve the acquisition of 3D deformation fields in live humans and additional cadaver specimens.

AB - A quantitative three-dimensional (3D) description of the deformation of brain tissue during acceleration of the skull is necessary to provide understanding of the underlying mechanisms of traumatic brain injury. Tagged magnetic resonance imaging (MRI) allows for the noninvasive measurement of the deformation of biological tissue. In this study, tagged MRI with harmonic phase (HARP) analysis was used to quantify the 3D deformation during angular acceleration of a gelatin phantom and the head of a human cadaver specimen. Two-dimensional results from the gelatin phantom showed good agreement with previously published results. Two-dimensional strains in the cadaver brain were lower in magnitude than previously reported results from a similar experiment in the live human brain. Strains on the inferior–superior axis were measured and shown to be of similar magnitude to the strain components in the plane formed by the anterior–posterior and left–right axes. Future studies will involve the acquisition of 3D deformation fields in live humans and additional cadaver specimens.

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PB - Springer New York

ER -

Using tagged MRI to quantify the 3D deformation of a cadaver brain in response to angular acceleration

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