Using sv119-gold nanocage conjugates to eradicate cancer stem cells through a combination of photothermal and chemo therapies

Tianmeng Sun, Yi Wang, Yucai Wang, Jinbin Xu, Xin Zhao, Suwanna Vangveravong, Robert H. Mach, Younan Xia

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Cancer stem cells (CSCs) are believed to be responsible for the long-term growth of a tumor, as well as its metastasis and recurrence after conventional therapies. Here, it is demonstrated that the sigma-2 receptor is overexpressed on the surface of breast CSCs, and thus could serve as a biomarker for the purpose of targeting. Breast CSCs are targeted with Au nanocages (AuNCs) by functionalizing their surfaces with SV119, a synthetic small molecule capable of binding to the sigma-2 receptor with high specificity. The interiors of the AuNCs could also be loaded with an anticancer drug to be selectively delivered to breast CSCs and released in a controllable fashion. The results demonstrate that the SV119-AuNC conjugate can serve as a new platform to carry out photothermal and chemo therapies simultaneously, eradicating breast CSCs more effectively through a synergetic effect.

Original languageEnglish
Pages (from-to)1283-1291
Number of pages9
JournalAdvanced Healthcare Materials
Volume3
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Cancer stem cells
  • Gold nanocages
  • SV119
  • Sigma-2 receptor
  • Synergetic effect

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