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Using steric hindrance to design new inhibitors of class C β-lactamases
Indi Trehan
, Federica Morandi
, Larry C. Blaszczak
, Brian K. Shoichet
Division of Emergency Medicine
Research output
:
Contribution to journal
›
Article
›
peer-review
37
Scopus citations
Overview
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Keyphrases
β-lactamase
100%
New Inhibitors
100%
Steric Hindrance
100%
Penicillin
100%
2-amino-4
60%
Thiazolyl
60%
Third-generation Cephalosporins
40%
Acyl
40%
Lactams
40%
Side Chain
20%
Antibiotics
20%
β-lactam Antibiotics
20%
Inhibitor Design
20%
Specific Group
20%
Incompetence
20%
Cephalosporins
20%
Deacylation
20%
Sterically Hindered
20%
Amoxicillin
20%
β-lactamase Inhibitor
20%
Inhibitor-2
20%
Transferability
20%
Design Guide
20%
Anti-resistance
20%
Pharmacology, Toxicology and Pharmaceutical Science
Penicillinase
100%
Penicillin
100%
Lactam
40%
Third Generation Cephalosporin
40%
Antibiotics
20%
Beta Lactam Antibiotic
20%
Cephalosporin Derivative
20%
Amoxicillin
20%
Carbacephem Derivative
20%