TY - JOUR
T1 - Using phosphatidylserine exposure on apoptotic cells to stimulate myoblast fusion
AU - Hochreiter-Hufford, Amelia E.
AU - Arandjelovic, Sanja
AU - Ravichandran, Kodi S.
N1 - Publisher Copyright:
© Springer Science+Business Media New York 2015.
PY - 2015
Y1 - 2015
N2 - The fusion of myoblasts, the skeletal muscle progenitors, is critical for skeletal muscle formation, function, and repair after muscle injury. Recognition of the phospholipid phosphatidylserine (PtdSer) exposed on certain myoblasts is required during fusion into multinuclear myofi bers. Cell surface exposure of PtdSer is also a feature of cells dying through the process of apoptosis. Here, we describe the use of PtdSer exposing apoptotic cells as stimulators of myoblast fusion.
AB - The fusion of myoblasts, the skeletal muscle progenitors, is critical for skeletal muscle formation, function, and repair after muscle injury. Recognition of the phospholipid phosphatidylserine (PtdSer) exposed on certain myoblasts is required during fusion into multinuclear myofi bers. Cell surface exposure of PtdSer is also a feature of cells dying through the process of apoptosis. Here, we describe the use of PtdSer exposing apoptotic cells as stimulators of myoblast fusion.
KW - Apoptotic cells
KW - BAI1
KW - Myoblast fusion
KW - Phosphatidylserine recognition
UR - http://www.scopus.com/inward/record.url?scp=84957086807&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-2703-6_10
DO - 10.1007/978-1-4939-2703-6_10
M3 - Article
C2 - 25947662
AN - SCOPUS:84957086807
SN - 1064-3745
VL - 1313
SP - 141
EP - 148
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -