Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example

Cheryl F. Lichti; Xiaoxiao Wan

doi:10.1016/j.smim.2023.101730

Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example

Research output: Contribution to journal › Review article › peer-review

Abstract

In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or autoreactive T cells. Post-translational modification (PTM) may alter the MHC-binding motif or TCR contact residues in a peptide antigen, transforming the tolerance to self to autoreactivity. Mass spectrometry-based immunopeptidomics provides a valuable mechanism for identifying MHC ligands that contain PTMs and can thus provide valuable insights into pathogenesis and therapeutics of autoimmune diseases. A plethora of PTMs have been implicated in this process, and this review highlights their formation and identification.

Original language	English
Article number	101730
Journal	Seminars in immunology
Volume	66
DOIs	https://doi.org/10.1016/j.smim.2023.101730
State	Published - Mar 2023

Keywords

Antigen presentation
Autoimmunity
ER stress
Immunopeptidomics
Neoantigen
Oxidative stress
Type 1 diabetes

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10.1016/j.smim.2023.101730

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@article{adad09c1b2604f9f8574d7c6d4eb7357,

title = "Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example",

abstract = "In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or autoreactive T cells. Post-translational modification (PTM) may alter the MHC-binding motif or TCR contact residues in a peptide antigen, transforming the tolerance to self to autoreactivity. Mass spectrometry-based immunopeptidomics provides a valuable mechanism for identifying MHC ligands that contain PTMs and can thus provide valuable insights into pathogenesis and therapeutics of autoimmune diseases. A plethora of PTMs have been implicated in this process, and this review highlights their formation and identification.",

keywords = "Antigen presentation, Autoimmunity, ER stress, Immunopeptidomics, Neoantigen, Oxidative stress, Type 1 diabetes",

author = "Lichti, \{Cheryl F.\} and Xiaoxiao Wan",

note = "Funding Information: During preparation of this manuscript, our colleague and mentor, Prof. Emil R. Unanue, passed away. He leaves a lasting legacy in the field of antigen processing and presentation, and we gratefully dedicate this article to his memory. We apologize for any inadvertent omissions of publications related to different topics discussed in this article. This work is supported by Diabetes Research Center at Washington University ( P30 DK020579 to X.W.), and Juvenile Diabetes Research Foundation ( 5-CDA-2022-1175-A-N to X.W.). All figures were created with BioRender.com. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = mar,

doi = "10.1016/j.smim.2023.101730",

language = "English",

volume = "66",

journal = "Seminars in immunology",

issn = "1044-5323",

}

TY - JOUR

T1 - Using mass spectrometry to identify neoantigens in autoimmune diseases

T2 - The type 1 diabetes example

AU - Lichti, Cheryl F.

AU - Wan, Xiaoxiao

N1 - Funding Information: During preparation of this manuscript, our colleague and mentor, Prof. Emil R. Unanue, passed away. He leaves a lasting legacy in the field of antigen processing and presentation, and we gratefully dedicate this article to his memory. We apologize for any inadvertent omissions of publications related to different topics discussed in this article. This work is supported by Diabetes Research Center at Washington University ( P30 DK020579 to X.W.), and Juvenile Diabetes Research Foundation ( 5-CDA-2022-1175-A-N to X.W.). All figures were created with BioRender.com. Publisher Copyright: © 2023 Elsevier Ltd

PY - 2023/3

Y1 - 2023/3

N2 - In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or autoreactive T cells. Post-translational modification (PTM) may alter the MHC-binding motif or TCR contact residues in a peptide antigen, transforming the tolerance to self to autoreactivity. Mass spectrometry-based immunopeptidomics provides a valuable mechanism for identifying MHC ligands that contain PTMs and can thus provide valuable insights into pathogenesis and therapeutics of autoimmune diseases. A plethora of PTMs have been implicated in this process, and this review highlights their formation and identification.

AB - In autoimmune diseases, recognition of self-antigens presented by major histocompatibility complex (MHC) molecules elicits unexpected attack of tissue by autoantibodies and/or autoreactive T cells. Post-translational modification (PTM) may alter the MHC-binding motif or TCR contact residues in a peptide antigen, transforming the tolerance to self to autoreactivity. Mass spectrometry-based immunopeptidomics provides a valuable mechanism for identifying MHC ligands that contain PTMs and can thus provide valuable insights into pathogenesis and therapeutics of autoimmune diseases. A plethora of PTMs have been implicated in this process, and this review highlights their formation and identification.

KW - Antigen presentation

KW - Autoimmunity

KW - ER stress

KW - Immunopeptidomics

KW - Neoantigen

KW - Oxidative stress

KW - Type 1 diabetes

UR - https://www.scopus.com/pages/publications/85149818329

U2 - 10.1016/j.smim.2023.101730

DO - 10.1016/j.smim.2023.101730

M3 - Review article

C2 - 36827760

AN - SCOPUS:85149818329

SN - 1044-5323

VL - 66

JO - Seminars in immunology

JF - Seminars in immunology

M1 - 101730

ER -

Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example

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Keywords

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