Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

Milan G. Chheda; David H. Gutmann

doi:10.1016/j.ccell.2017.04.008

Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

Milan G. Chheda, David H. Gutmann

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.

Original language	English
Pages (from-to)	609-611
Number of pages	3
Journal	Cancer Cell
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.ccell.2017.04.008
State	Published - May 8 2017

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title = "Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer",

abstract = "In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.",

author = "Chheda, {Milan G.} and Gutmann, {David H.}",

note = "Funding Information: D.H.G. is supported by a Research Program Award from the National Institute of Neurological Disorders and Stroke (1-R35-NS097211-01). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

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AU - Chheda, Milan G.

AU - Gutmann, David H.

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PY - 2017/5/8

Y1 - 2017/5/8

N2 - In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.

AB - In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.

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DO - 10.1016/j.ccell.2017.04.008

M3 - Short survey

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AN - SCOPUS:85019146910

SN - 1535-6108

VL - 31

SP - 609

EP - 611

JO - Cancer Cell

JF - Cancer Cell

IS - 5

ER -

Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

Abstract

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