Using Caenorhabditis elegans to study serpinopathies

Olivia S. Long, Sager J. Gosai, Joon Hyeok Kwak, Dale E. King, David H. Perlmutter, Gary A. Silverman, Stephen C. Pak

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Protein misfolding, polymerization, and/or aggregation are hallmarks of serpinopathies and many other human genetic disorders including Alzheimer's, Huntington's, and Parkinson's disease. While higher organism models have helped shape our understanding of these diseases, simpler model systems, like Caenorhabditis elegans, offer great versatility for elucidating complex genetic mechanisms underlying these diseases. Moreover, recent advances in automated high-throughput methodologies have promoted C. elegans as a useful tool for drug discovery. In this chapter, we describe how one could model serpinopathies in C. elegans and how one could exploit this model to identify small molecule compounds that can be developed into effective therapeutic drugs.

Original languageEnglish
Title of host publicationMethods in Enzymology
PublisherAcademic Press Inc.
Pages259-281
Number of pages23
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameMethods in Enzymology
Volume499
ISSN (Print)0076-6879
ISSN (Electronic)1557-7988

Keywords

  • Caenorhabditis elegans
  • High-content screening
  • Protein polymerization
  • Serpinopathies

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    Long, O. S., Gosai, S. J., Kwak, J. H., King, D. E., Perlmutter, D. H., Silverman, G. A., & Pak, S. C. (2011). Using Caenorhabditis elegans to study serpinopathies. In Methods in Enzymology (pp. 259-281). (Methods in Enzymology; Vol. 499). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-386471-0.00013-4