Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence

Eugene Milshteyn, Cornelius von Morze, Galen D. Reed, Hong Shang, Peter J. Shin, Peder E.Z. Larson, Daniel B. Vigneron

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Acceleration of dynamic 2D (T2 Mapping) and 3D hyperpolarized 13C MRI acquisitions using the balanced steady-state free precession sequence was achieved with a specialized reconstruction method, based on the combination of low rank plus sparse and local low rank reconstructions. Methods were validated using both retrospectively and prospectively undersampled in vivo data from normal rats and tumor-bearing mice. Four-fold acceleration of 1–2 mm isotropic 3D dynamic acquisitions with 2–5 s temporal resolution and two-fold acceleration of 0.25–1 mm2 2D dynamic acquisitions was achieved. This enabled visualization of the biodistribution of [2-13C]pyruvate, [1-13C]lactate, [13C, 15N2]urea, and HP001 within heart, kidneys, vasculature, and tumor, as well as calculation of high resolution T2 maps.

Original languageEnglish
Pages (from-to)46-59
Number of pages14
JournalJournal of Magnetic Resonance
Volume290
DOIs
StatePublished - May 2018

Keywords

  • C
  • Hyperpolarized
  • Local low rank
  • SSFP
  • Sparse

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