Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

Yazan Fahmawi; Clayton Smith; Leander Grimm; Shikha Khullar; Paul Rider; John Hunter; Greire Iliff; Wadad Mneimneh; Kelly Roveda; Bin Wang; Pranitha Prodduturvar; Omar Alkharabsheh; Ben McCormick; Meir Mizrahi; Moh'd Khushman

doi:10.1016/j.clcc.2020.06.006

Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

Yazan Fahmawi, Clayton Smith, Leander Grimm, Shikha Khullar, Paul Rider, John Hunter, Greire Iliff, Wadad Mneimneh, Kelly Roveda, Bin Wang, Pranitha Prodduturvar, Omar Alkharabsheh, Ben McCormick, Meir Mizrahi, Moh'd Khushman

Section of Medical Oncology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In an attempt to identify short-term surrogate endpoints that would predict long-term survival in patients with patients with locally advanced rectal cancer, we explored the usefulness of performing restaging magnetic resonance imaging (MRI). We tested the agreement between restaging MRI T (yT) and N (yN) with ypT and ypN stages, respectively, and explored the prognostic significance of restaging MRI neoadjuvant rectal (NAR) score. Restaging pelvis MRI could not predict ypT or ypN stage. The mean MRI NAR (mNAR) score was higher than the mean NAR score. There was a trend for longer DFS and OS in patients with low-intermediate mNAR score compared to patients with high mNAR scores.

Original language	English
Pages (from-to)	e281-e287
Journal	Clinical Colorectal Cancer
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.clcc.2020.06.006
State	Published - Dec 2020

Keywords

MRI
NAR
Neoadjuvant rectal score
Prognostic significance
Surrogate endpoint

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10.1016/j.clcc.2020.06.006

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Fahmawi, Y., Smith, C., Grimm, L., Khullar, S., Rider, P., Hunter, J., Iliff, G., Mneimneh, W., Roveda, K., Wang, B., Prodduturvar, P., Alkharabsheh, O., McCormick, B., Mizrahi, M., & Khushman, M. (2020). Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer. Clinical Colorectal Cancer, 19(4), e281-e287. https://doi.org/10.1016/j.clcc.2020.06.006

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title = "Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer",

abstract = "In an attempt to identify short-term surrogate endpoints that would predict long-term survival in patients with patients with locally advanced rectal cancer, we explored the usefulness of performing restaging magnetic resonance imaging (MRI). We tested the agreement between restaging MRI T (yT) and N (yN) with ypT and ypN stages, respectively, and explored the prognostic significance of restaging MRI neoadjuvant rectal (NAR) score. Restaging pelvis MRI could not predict ypT or ypN stage. The mean MRI NAR (mNAR) score was higher than the mean NAR score. There was a trend for longer DFS and OS in patients with low-intermediate mNAR score compared to patients with high mNAR scores.",

keywords = "MRI, NAR, Neoadjuvant rectal score, Prognostic significance, Surrogate endpoint",

author = "Yazan Fahmawi and Clayton Smith and Leander Grimm and Shikha Khullar and Paul Rider and John Hunter and Greire Iliff and Wadad Mneimneh and Kelly Roveda and Bin Wang and Pranitha Prodduturvar and Omar Alkharabsheh and Ben McCormick and Meir Mizrahi and Moh'd Khushman",

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year = "2020",

month = dec,

doi = "10.1016/j.clcc.2020.06.006",

language = "English",

volume = "19",

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Fahmawi, Y, Smith, C, Grimm, L, Khullar, S, Rider, P, Hunter, J, Iliff, G, Mneimneh, W, Roveda, K, Wang, B, Prodduturvar, P, Alkharabsheh, O, McCormick, B, Mizrahi, M & Khushman, M 2020, 'Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer', Clinical Colorectal Cancer, vol. 19, no. 4, pp. e281-e287. https://doi.org/10.1016/j.clcc.2020.06.006

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T1 - Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

AU - Fahmawi, Yazan

AU - Smith, Clayton

AU - Grimm, Leander

AU - Khullar, Shikha

AU - Rider, Paul

AU - Hunter, John

AU - Iliff, Greire

AU - Mneimneh, Wadad

AU - Roveda, Kelly

AU - Wang, Bin

AU - Prodduturvar, Pranitha

AU - Alkharabsheh, Omar

AU - McCormick, Ben

AU - Mizrahi, Meir

AU - Khushman, Moh'd

PY - 2020/12

Y1 - 2020/12

N2 - In an attempt to identify short-term surrogate endpoints that would predict long-term survival in patients with patients with locally advanced rectal cancer, we explored the usefulness of performing restaging magnetic resonance imaging (MRI). We tested the agreement between restaging MRI T (yT) and N (yN) with ypT and ypN stages, respectively, and explored the prognostic significance of restaging MRI neoadjuvant rectal (NAR) score. Restaging pelvis MRI could not predict ypT or ypN stage. The mean MRI NAR (mNAR) score was higher than the mean NAR score. There was a trend for longer DFS and OS in patients with low-intermediate mNAR score compared to patients with high mNAR scores.

AB - In an attempt to identify short-term surrogate endpoints that would predict long-term survival in patients with patients with locally advanced rectal cancer, we explored the usefulness of performing restaging magnetic resonance imaging (MRI). We tested the agreement between restaging MRI T (yT) and N (yN) with ypT and ypN stages, respectively, and explored the prognostic significance of restaging MRI neoadjuvant rectal (NAR) score. Restaging pelvis MRI could not predict ypT or ypN stage. The mean MRI NAR (mNAR) score was higher than the mean NAR score. There was a trend for longer DFS and OS in patients with low-intermediate mNAR score compared to patients with high mNAR scores.

KW - MRI

KW - NAR

KW - Neoadjuvant rectal score

KW - Prognostic significance

KW - Surrogate endpoint

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SN - 1533-0028

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JO - Clinical Colorectal Cancer

JF - Clinical Colorectal Cancer

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ER -

Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

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