We investigated the feasibility of videophones for the delivery of problem-solving therapy (PST) for informal hospice caregivers. Informal hospice caregivers were randomly assigned to receive PST from researchers using videophones, instead of communicating in face-to-face sessions. Outcome measures included caregiver anxiety, quality of life and problem solving abilities, technical quality of video sessions and satisfaction of participants (including both subjects and researchers). A total of 42 hospice caregivers were enrolled (mean age 62 years). A total of 112 video call attempts were documented. Of these, 100 (89%) resulted in successful video calls and 12 (11%) were cases in which a call was not established. The average video call duration was 38 min (range 18-84 min). The overall technical quality of the video calls was very good. Caregivers reported a slightly higher quality of life post-intervention than at baseline, although this was not significant. Caregivers reported lower levels of anxiety post-intervention than at baseline (P 1/4 0.04). The subjects were generally satisfied with the videophones during their exit interviews.