Use of transgenic mice to characterize the multipotent intestinal stem cell and to analyze regulation of gene expression in various epithelial cell lineages as a function of their position along the cephalocaudal and crypt-to-villus (or crypt-to-surface epithelial cuff) axes of the gut

Michelle L. Hermiston, Jeffrey I. Gordon

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The processes of cell proliferation, lineage allocation and differentiation occur continuously and rapidly along the crypt-to-villus axis of the small intestine and the crypt-to-surface epithelial cuff axis of the colon. The four principal epithelial cell lineages in the gut are derived from a multipotent stem cell. Current evidence suggests that each small intestinal and colonic crypt contains a single active stem cell. The biological properties of these stem cells can be inferred from the properties of their amplified, spatially constrained, descendants. Recent studies in transgenic mice have provided insights about how axial pattern formation is maintained in this perpetually renewing epithelium.

Original languageEnglish
Pages (from-to)275-291
Number of pages17
JournalSeminars in Developmental Biology
Volume4
Issue number5
DOIs
StatePublished - Oct 1993

Keywords

  • differentiation/lineage allocation/pattern formation/stem cells/transgenic mice

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