TY - JOUR
T1 - Use of transgenic mice to characterize the multipotent intestinal stem cell and to analyze regulation of gene expression in various epithelial cell lineages as a function of their position along the cephalocaudal and crypt-to-villus (or crypt-to-surface epithelial cuff) axes of the gut
AU - Hermiston, Michelle L.
AU - Gordon, Jeffrey I.
PY - 1993/10
Y1 - 1993/10
N2 - The processes of cell proliferation, lineage allocation and differentiation occur continuously and rapidly along the crypt-to-villus axis of the small intestine and the crypt-to-surface epithelial cuff axis of the colon. The four principal epithelial cell lineages in the gut are derived from a multipotent stem cell. Current evidence suggests that each small intestinal and colonic crypt contains a single active stem cell. The biological properties of these stem cells can be inferred from the properties of their amplified, spatially constrained, descendants. Recent studies in transgenic mice have provided insights about how axial pattern formation is maintained in this perpetually renewing epithelium.
AB - The processes of cell proliferation, lineage allocation and differentiation occur continuously and rapidly along the crypt-to-villus axis of the small intestine and the crypt-to-surface epithelial cuff axis of the colon. The four principal epithelial cell lineages in the gut are derived from a multipotent stem cell. Current evidence suggests that each small intestinal and colonic crypt contains a single active stem cell. The biological properties of these stem cells can be inferred from the properties of their amplified, spatially constrained, descendants. Recent studies in transgenic mice have provided insights about how axial pattern formation is maintained in this perpetually renewing epithelium.
KW - differentiation/lineage allocation/pattern formation/stem cells/transgenic mice
UR - http://www.scopus.com/inward/record.url?scp=0000364928&partnerID=8YFLogxK
U2 - 10.1006/sedb.1993.1031
DO - 10.1006/sedb.1993.1031
M3 - Article
AN - SCOPUS:0000364928
SN - 1044-5781
VL - 4
SP - 275
EP - 291
JO - Seminars in Developmental Biology
JF - Seminars in Developmental Biology
IS - 5
ER -