Use of the Clinac 35 for tissue activation in noninvasive measurement of capillary blood flow

Gilbert H. Nussbaum; James A. Purdy; Conrad O. Granda; Bahman Emami; Stephen A. Sapareto

doi:10.1118/1.595395

Use of the Clinac 35 for tissue activation in noninvasive measurement of capillary blood flow

Gilbert H. Nussbaum, James A. Purdy, Conrad O. Granda, Bahman Emami, Stephen A. Sapareto

Department of Radiation Oncology

Research output: Contribution to journal › Letter › peer-review

9 Scopus citations

Abstract

Through adjustment of operating parameters responsible for the acceleration, steering, and focusing of electrons en route to the target, we have extracted a 30 MV x ray beam from the Clinac 35 linear accelerator that is suitable for use in photon activation ⁻¹⁵O decay studies of tissue perfusion. This beam is significantly more efficient than the “standard” 25 MV beam in producing ¹⁵O in situ through activation of tissue oxygen, thereby substantially reducing the dose to tissue required to yield a desired initial ¹⁵O activity. Production and characteristics of the higher energy beam are discussed, and data obtained from its application to measurement of capillary blood flow in animal tumors are presented and analyzed.

Original language	English
Pages (from-to)	487-490
Number of pages	4
Journal	Medical physics
Volume	10
Issue number	4
DOIs	https://doi.org/10.1118/1.595395
State	Published - Jul 1983

Keywords

animals
beam production
blood
electron beams
fluid flow
focusing
linear accelerators
neoplasms
operation
oxygen 15

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title = "Use of the Clinac 35 for tissue activation in noninvasive measurement of capillary blood flow",

abstract = "Through adjustment of operating parameters responsible for the acceleration, steering, and focusing of electrons en route to the target, we have extracted a 30 MV x ray beam from the Clinac 35 linear accelerator that is suitable for use in photon activation −15O decay studies of tissue perfusion. This beam is significantly more efficient than the “standard” 25 MV beam in producing 15O in situ through activation of tissue oxygen, thereby substantially reducing the dose to tissue required to yield a desired initial 15O activity. Production and characteristics of the higher energy beam are discussed, and data obtained from its application to measurement of capillary blood flow in animal tumors are presented and analyzed.",

keywords = "animals, beam production, blood, electron beams, fluid flow, focusing, linear accelerators, neoplasms, operation, oxygen 15",

author = "Nussbaum, {Gilbert H.} and Purdy, {James A.} and Granda, {Conrad O.} and Bahman Emami and Sapareto, {Stephen A.}",

year = "1983",

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AU - Nussbaum, Gilbert H.

AU - Purdy, James A.

AU - Granda, Conrad O.

AU - Emami, Bahman

AU - Sapareto, Stephen A.

PY - 1983/7

Y1 - 1983/7

N2 - Through adjustment of operating parameters responsible for the acceleration, steering, and focusing of electrons en route to the target, we have extracted a 30 MV x ray beam from the Clinac 35 linear accelerator that is suitable for use in photon activation −15O decay studies of tissue perfusion. This beam is significantly more efficient than the “standard” 25 MV beam in producing 15O in situ through activation of tissue oxygen, thereby substantially reducing the dose to tissue required to yield a desired initial 15O activity. Production and characteristics of the higher energy beam are discussed, and data obtained from its application to measurement of capillary blood flow in animal tumors are presented and analyzed.

AB - Through adjustment of operating parameters responsible for the acceleration, steering, and focusing of electrons en route to the target, we have extracted a 30 MV x ray beam from the Clinac 35 linear accelerator that is suitable for use in photon activation −15O decay studies of tissue perfusion. This beam is significantly more efficient than the “standard” 25 MV beam in producing 15O in situ through activation of tissue oxygen, thereby substantially reducing the dose to tissue required to yield a desired initial 15O activity. Production and characteristics of the higher energy beam are discussed, and data obtained from its application to measurement of capillary blood flow in animal tumors are presented and analyzed.

KW - animals

KW - beam production

KW - blood

KW - electron beams

KW - fluid flow

KW - focusing

KW - linear accelerators

KW - neoplasms

KW - operation

KW - oxygen 15

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Use of the Clinac 35 for tissue activation in noninvasive measurement of capillary blood flow

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Keywords

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