Use of magnetic resonance imaging as well as clinical disease activity in the clinical classification of multiple sclerosis and assessment of its course

Stuart D. Cook, Suhayl Dhib-Jalbut, Peter Dowling, Luca Durelli, Corey Ford, Gavin Giovannoni, June Halper, Colleen Harris, Joseph Herbert, David Li, John A. Lincoln, Robert Lisak, Fred D. Lublin, Claudia F. Lucchinetti, Wayne Moore, Robert T. Naismith, Carlos Oehninger, Jack Simo, Maria Pia Sormani

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

It has recently been suggested that the Lublin-Reingold clinical classification of multiple sclerosis (MS) be modified to include the use of magnetic resonance imaging (MRI). An international consensus conference sponsored by the Consortium of Multiple Sclerosis Centers (CMSC) was held from March 5 to 7, 2010, to review the available evidence on the need for such modification of the Lublin-Reingold criteria and whether the addition of MRI or other biomarkers might lead to a better understanding of MS pathophysiology and disease course over time. The conference participants concluded that evidence of new MRI gadolinium-enhancing (Gd+) T1-weighted lesions and unequivocally new or enlarging T2-weighted lesions (subclinical activity, subclinical relapses) should be added to the clinical classification of MS in distinguishing relapsing inflammatory from progressive forms of the disease. The consensus was that these changes to the classification system would provide more rigorous definitions and categorization of MS course, leading to better insights as to the evolution and treatment of MS.

Original languageEnglish
Pages (from-to)105-114
Number of pages10
JournalInternational Journal of MS Care
Volume14
Issue number3
DOIs
StatePublished - 2012

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