Use of genetic profiling in leprosy to discriminate clinical forms of the disease

Joshua R. Bleharski; Huiying Li; Christoph Meinken; Thomas G. Graeber; Maria Teresa Ochoa; Masahiro Yamamura; Anne Burdick; Euzenir N. Sarno; Manfred Wagner; Martin Röllinghoff; Thomas H. Rea; Marco Colonna; Steffen Stenger; Barry R. Bloom; David Eisenberg; Robert L. Modlin

doi:10.1126/science.1087785

Use of genetic profiling in leprosy to discriminate clinical forms of the disease

Joshua R. Bleharski, Huiying Li, Christoph Meinken, Thomas G. Graeber, Maria Teresa Ochoa, Masahiro Yamamura, Anne Burdick, Euzenir N. Sarno, Manfred Wagner, Martin Röllinghoff, Thomas H. Rea, Marco Colonna, Steffen Stenger, Barry R. Bloom, David Eisenberg, Robert L. Modlin

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151 Scopus citations

Abstract

Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease, Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.

Original language	English
Pages (from-to)	1527-1530
Number of pages	4
Journal	Science
Volume	301
Issue number	5639
DOIs	https://doi.org/10.1126/science.1087785
State	Published - Sep 12 2003

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Bleharski, J. R., Li, H., Meinken, C., Graeber, T. G., Ochoa, M. T., Yamamura, M., Burdick, A., Sarno, E. N., Wagner, M., Röllinghoff, M., Rea, T. H., Colonna, M., Stenger, S., Bloom, B. R., Eisenberg, D., & Modlin, R. L. (2003). Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science, 301(5639), 1527-1530. https://doi.org/10.1126/science.1087785

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abstract = "Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease, Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.",

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AU - Bleharski, Joshua R.

AU - Li, Huiying

AU - Meinken, Christoph

AU - Graeber, Thomas G.

AU - Ochoa, Maria Teresa

AU - Yamamura, Masahiro

AU - Burdick, Anne

AU - Sarno, Euzenir N.

AU - Wagner, Manfred

AU - Röllinghoff, Martin

AU - Rea, Thomas H.

AU - Colonna, Marco

AU - Stenger, Steffen

AU - Bloom, Barry R.

AU - Eisenberg, David

AU - Modlin, Robert L.

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AB - Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease, Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.

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Use of genetic profiling in leprosy to discriminate clinical forms of the disease

Abstract

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