TY - JOUR
T1 - Use of cohort data to estimate national prevalence of transmitted drug resistance to antiretroviral drugs in Spain (2007-2012)
AU - Cohorte de la Red de Investigación en Sida (CoRIS)
AU - Monge, S.
AU - Díez, M.
AU - Alvarez, M.
AU - Guillot, V.
AU - Iribarren, J. A.
AU - Palacios, R.
AU - Delgado, R.
AU - Jaén, A.
AU - Blanco, J. R.
AU - Domingo, P.
AU - Portilla, J.
AU - Pérez Elías, M. J.
AU - Garcia, F.
AU - del Amo, Julia
AU - García, Federico
AU - Muñoz, María Ángeles
AU - Vegas, Paz Sobrino
AU - Sebastián, Victoria Hernando
AU - Ferreras, Belén Alejos
AU - Álvarez, Débora
AU - Jarrín, Inma
AU - Muñoz-Fernández, M. Ángeles
AU - García-Merino, Isabel
AU - Rico, Coral Gómez
AU - de la Fuente, Jorge Gallego
AU - Torre, Almudena García
AU - de Lucas, Esperanza Merino
AU - Bañuls, Sergio Reus
AU - Martínez, Vicente Boix
AU - Oncina, Livia Giner
AU - Pastor, Carmen Gadea
AU - Tamarit, Irene Portilla
AU - Toledo, Patricia Arcaina
AU - Asensi, Victor
AU - Valle, Eulalia
AU - Cartón, José Antonio
AU - Sirvent, Juan Luis Gómez
AU - Fortúnez, Patricia Rodríguez
AU - Valls, María Remedios Alemán
AU - Socas, María del Mar Alonso
AU - Hernández, María Inmaculada Hernández
AU - Díaz-Flores, Felicitas
AU - Rosado, Dácil García
AU - González, Ricardo Pelazas
AU - Soriano, Vicente
AU - Labarga, Pablo
AU - Barreiro, Pablo
AU - Blanco, Francisco
AU - Carbonero, Luz Martín
AU - Ibáñez, Laura
N1 - Funding Information:
The RIS cohort (CoRIS) is funded by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en Sida ( ISCIII-RETIC RD06/0006/0026 ). This work was also partially funded by ISCIII Grant no. PI12/01053 .
Publisher Copyright:
© 2014 European Society of Clinical Microbiology and Infectious Diseases.
PY - 2015
Y1 - 2015
N2 - Prevalence of transmitted drug resistance (pTDR) to antiretroviral drugs in Spain (2007-2012) was estimated using the CoRIS cohort, adjusting its territorial distribution and transmission route to the reference population from the Spanish Information System on New human immunodeficiency virus diagnoses. A total of 2702 patients from ten autonomous communities and with naive FASTA sequence within 6 months of human immunodeficiency virus diagnosis were selected. Weighted pTDR, estimated using the inverse probability of selection in the sample by autonomous communities and transmission group, was 8.12% (95% CI 6.44-9.80), not significantly different from unweighted pTDR. We illustrate how proportional weighting can maximize representativeness of cohort-based data, and its value to monitor pTDR at country level.
AB - Prevalence of transmitted drug resistance (pTDR) to antiretroviral drugs in Spain (2007-2012) was estimated using the CoRIS cohort, adjusting its territorial distribution and transmission route to the reference population from the Spanish Information System on New human immunodeficiency virus diagnoses. A total of 2702 patients from ten autonomous communities and with naive FASTA sequence within 6 months of human immunodeficiency virus diagnosis were selected. Weighted pTDR, estimated using the inverse probability of selection in the sample by autonomous communities and transmission group, was 8.12% (95% CI 6.44-9.80), not significantly different from unweighted pTDR. We illustrate how proportional weighting can maximize representativeness of cohort-based data, and its value to monitor pTDR at country level.
KW - Antiretroviral agents
KW - Cohort studies
KW - Drug resistance
KW - Epidemiological monitoring
KW - Human immunodeficiency virus
UR - http://www.scopus.com/inward/record.url?scp=84926285901&partnerID=8YFLogxK
U2 - 10.1016/j.cmi.2014.08.007
DO - 10.1016/j.cmi.2014.08.007
M3 - Article
C2 - 25636937
AN - SCOPUS:84926285901
SN - 1198-743X
VL - 21
SP - 105.e1-105.e5
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
IS - 1
ER -