Use of amplicon-based sequencing for testing fetal identity and monogenic traits with Single Circulating Trophoblast (SCT) as one form of cell-based NIPT

Keyphrases

• Cell-based 100%
• Monogenic 100%
• Single nucleotide Polymorphism 100%
• Amplicon Sequencing 100%
• Noninvasive Prenatal Testing 100%
• Circulating Trophoblasts 100%
• One-forms 100%
• Amplicon 33%
• Testing Cases 33%
• Cystic Fibrosis 33%
• HLA-B 33%
• Isolated Cells 33%
• Clinical Diagnosis 33%
• Highly Polymorphic 33%
• Genomic Regions 33%
• HLA-A 33%
• False Positive Rate 33%
• Sex Chromosomes 33%
• DNA Samples 33%
• Lymphoblastoid Cell Lines 33%
• Fetal Cells 33%
• Next-generation Sequencing Methods 33%
• Whole Genome Amplification 33%
• Cell Identification 33%
• Hemoglobinopathies 33%
• Tay-Sachs Disease 33%
• Applied Biosystems 33%
• Maternal Cell 33%
• Modification Methods 33%
• Human Identification 33%
• Pathogenic Variants 33%
• Major Challenges 33%
• Disease Variants 33%
• True Negative 33%
• General Validity 33%

Biochemistry, Genetics and Molecular Biology

• Single-Nucleotide Polymorphism 100%
• Amplicon 100%
• Genotyping 100%
• Trophoblast 100%
• Next Generation Sequencing 66%
• Cystic Fibrosis 33%
• Gene Amplification 33%
• Sex Chromosome 33%
• HLA-A 33%
• Tay-Sachs Disease 33%
• HLA-B 33%
• Genomics 33%