Use of a recombinant antigen (OC 3.6 cDNA) for the serological diagnosis of onchocerciasis in exposed Nigerian children

A. F. Ogunrinade, R. Chandrashekar, G. J. Weil, O. O. Kale

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Summary: We evaluated a recombinant antigen (OC 3.6 cDNA) expressed in pMAL TM vector for the diagnosis of onchocerciasis in children living in an endemic focus of forest-type onchocerciasis in Nigeria. Using the Western blot with the maltose-binding fusion protein as antigen, 91 per cent of mf-positive children and 24 per cent of endemic normal children were positive. Furthermore, age was not a limitation to the assay. The practical limitations of the assay for field diagnosis of onchocerciasis is discussed.

Original languageEnglish
Pages (from-to)103-105
Number of pages3
JournalJournal of Tropical Pediatrics
Volume38
Issue number3
DOIs
StatePublished - Jun 1 1992

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