TY - JOUR
T1 - Urological disorders in chronic kidney disease in children cohort
T2 - Clinical characteristics and estimation of glomerular filtration rate
AU - Dodson, Jennifer L.
AU - Jerry-Fluker, Judith V.
AU - Ng, Derek K.
AU - Moxey-Mims, Marva
AU - Schwartz, George J.
AU - Dharnidharka, Vikas R.
AU - Warady, Bradley A.
AU - Furth, Susan L.
N1 - Funding Information:
Data in this manuscript were created by the Chronic Kidney Disease in Children prospective cohort study (CKiD) with clinical coordinating centers (Principal Investigators) at Children's Mercy Hospital and the University of Missouri–Kansas City (BAW), Children's Hospital of Pennsylvania (SLF), Central Biochemistry Laboratory at the University of Rochester Medical Center (GJS), and data coordinating center (Principal Investigator) at the Johns Hopkins Bloomberg School of Public Health (Alvaro Muñoz, Ph.D.). The CKiD study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the National Institute of Neurological Disorders and Stroke, the National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01-DK-66143, U01-DK-66174, U01-CK-82194, U01-DK-66116). The project was also supported by grant 1K23DK078671 from the National Institute of Diabetes and Digestive and Kidney Diseases , AUA Foundation, National Cancer Institute and National Kidney Foundation of Maryland Professional Development Award (JLD). The CKiD website is located at http://www.statepi.jhsph.edu/ckid .
PY - 2011/10
Y1 - 2011/10
N2 - Purpose: Urological disorders are the most common cause of pediatric chronic kidney disease. We determined the characteristics of children with urological disorders and assessed the agreement between the newly developed bedside glomerular filtration rate estimating formula with measured glomerular filtration rate in 586 patients in the Chronic Kidney Disease in Children study. Materials and Methods: The Chronic Kidney Disease in Children study is a prospective, observational cohort of children recruited from 48 sites in the United States and Canada. Eligibility requirements include age 1 to 16 years and estimated glomerular filtration rate by original Schwartz formula 30 to 90 ml/min/1.73 m2. Baseline demographics, clinical variables and glomerular filtration rate were assessed. Bland-Altman analysis was conducted to assess agreement between estimated and measured glomerular filtration rates. Results: Of the 586 participants with at least 1 glomerular filtration rate measurement 348 (59%) had an underlying urological diagnosis (obstructive uropathy in 118, aplastic/hypoplastic/dysplastic kidneys in 104, reflux in 87 and other condition in 39). Among these patients median age was 9 years, duration of chronic kidney disease was 7 years and age at first visit with a urologist was less than 1 year. Of the patients 67% were male, 67% were white and 21% had a low birth weight. Median height was in the 24th percentile. Median glomerular filtration rate as measured by iohexol plasma disappearance was 44.8 ml/min/1.73 m2. Median glomerular filtration rate as estimated by the Chronic Kidney Disease in Children bedside equation was 44.3 ml/min/1.73 m2 (bias = -0.5, 95% CI -1.7 to 0.7, p = 0.44). Conclusions: Underlying urological causes of chronic kidney disease were present in 59% of study participants. These children were diagnosed early in life, and many had low birth weight and growth delay. There is good agreement between the newly developed Chronic Kidney Disease in Children estimating equations and measured glomerular filtration rate in this population.
AB - Purpose: Urological disorders are the most common cause of pediatric chronic kidney disease. We determined the characteristics of children with urological disorders and assessed the agreement between the newly developed bedside glomerular filtration rate estimating formula with measured glomerular filtration rate in 586 patients in the Chronic Kidney Disease in Children study. Materials and Methods: The Chronic Kidney Disease in Children study is a prospective, observational cohort of children recruited from 48 sites in the United States and Canada. Eligibility requirements include age 1 to 16 years and estimated glomerular filtration rate by original Schwartz formula 30 to 90 ml/min/1.73 m2. Baseline demographics, clinical variables and glomerular filtration rate were assessed. Bland-Altman analysis was conducted to assess agreement between estimated and measured glomerular filtration rates. Results: Of the 586 participants with at least 1 glomerular filtration rate measurement 348 (59%) had an underlying urological diagnosis (obstructive uropathy in 118, aplastic/hypoplastic/dysplastic kidneys in 104, reflux in 87 and other condition in 39). Among these patients median age was 9 years, duration of chronic kidney disease was 7 years and age at first visit with a urologist was less than 1 year. Of the patients 67% were male, 67% were white and 21% had a low birth weight. Median height was in the 24th percentile. Median glomerular filtration rate as measured by iohexol plasma disappearance was 44.8 ml/min/1.73 m2. Median glomerular filtration rate as estimated by the Chronic Kidney Disease in Children bedside equation was 44.3 ml/min/1.73 m2 (bias = -0.5, 95% CI -1.7 to 0.7, p = 0.44). Conclusions: Underlying urological causes of chronic kidney disease were present in 59% of study participants. These children were diagnosed early in life, and many had low birth weight and growth delay. There is good agreement between the newly developed Chronic Kidney Disease in Children estimating equations and measured glomerular filtration rate in this population.
KW - congenital, hereditary, and neonatal diseases and abnormalities
KW - glomerular filtration rate
KW - kidney failure, chronic
KW - pediatrics
KW - urology
UR - http://www.scopus.com/inward/record.url?scp=80052764162&partnerID=8YFLogxK
U2 - 10.1016/j.juro.2011.05.059
DO - 10.1016/j.juro.2011.05.059
M3 - Article
C2 - 21855938
AN - SCOPUS:80052764162
SN - 0022-5347
VL - 186
SP - 1460
EP - 1466
JO - Journal of Urology
JF - Journal of Urology
IS - 4
ER -