Urokinase-type plasminogen activator stimulates the ras/extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of Grb2/Sos-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells

Diem H.D. Nguyen, Donna J. Webb, Andrew D. Catling, Qian Song, Anita Dhakephalkar, Michael J. Weber, Kodimangalam S. Ravichandran, Steven L. Gonias

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Fingerprint

Dive into the research topics of 'Urokinase-type plasminogen activator stimulates the ras/extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of Grb2/Sos-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells'. Together they form a unique fingerprint.

Keyphrases

Biochemistry, Genetics and Molecular Biology

Neuroscience