Urokinase-type plasminogen activator stimulates the ras/extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of Grb2/Sos-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells
Diem H.D. Nguyen, Donna J. Webb, Andrew D. Catling, Qian Song, Anita Dhakephalkar, Michael J. Weber, Kodimangalam S. Ravichandran, Steven L. Gonias
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