TY - JOUR
T1 - Urinary tract infections
T2 - microbial pathogenesis, host–pathogen interactions and new treatment strategies
AU - Klein, Roger D.
AU - Hultgren, Scott J.
N1 - Funding Information:
The authors thank K. W. Dodson and T. J. Hannan for their helpful suggestions and comments on the manuscript. Work in the authors’ laboratory was supported by grants AI099099, AI095542, AI029549 and AI048689 from the US National Institution of Allergy and Infectious Diseases, grants DK051406 and DK108840 from the US National Institute of Diabetes and Digestive and Kidney Diseases and Medical Scientist Training Program Grant T32GM07200 from the US National Institute of General Medical Sciences. The authors apologize to researchers whose work was not included in this Review due to space constraints.
Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-threatening. The continued emergence of antibiotic resistance, together with our increasing understanding of the detrimental effects conferred by broad-spectrum antibiotic use on the health of the beneficial microbiota of the host, has underscored the weaknesses in our current treatment paradigm for UTIs. In this Review, we discuss how recent microbiological, structural, genetic and immunological studies have expanded our understanding of host–pathogen interactions during UTI pathogenesis. These basic scientific findings have the potential to shift the strategy for UTI treatment away from broad-spectrum antibiotics targeting conserved aspects of bacterial replication towards pathogen-specific antibiotic-sparing therapeutics that target core determinants of bacterial virulence at the host–pathogen interface.
AB - Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-threatening. The continued emergence of antibiotic resistance, together with our increasing understanding of the detrimental effects conferred by broad-spectrum antibiotic use on the health of the beneficial microbiota of the host, has underscored the weaknesses in our current treatment paradigm for UTIs. In this Review, we discuss how recent microbiological, structural, genetic and immunological studies have expanded our understanding of host–pathogen interactions during UTI pathogenesis. These basic scientific findings have the potential to shift the strategy for UTI treatment away from broad-spectrum antibiotics targeting conserved aspects of bacterial replication towards pathogen-specific antibiotic-sparing therapeutics that target core determinants of bacterial virulence at the host–pathogen interface.
UR - http://www.scopus.com/inward/record.url?scp=85079814454&partnerID=8YFLogxK
U2 - 10.1038/s41579-020-0324-0
DO - 10.1038/s41579-020-0324-0
M3 - Review article
C2 - 32071440
AN - SCOPUS:85079814454
SN - 1740-1526
VL - 18
SP - 211
EP - 226
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 4
ER -