Urinary tract infections: Epidemiology, mechanisms of infection and treatment options

Ana L. Flores-Mireles, Jennifer N. Walker, Michael Caparon, Scott J. Hultgren

Research output: Contribution to journalReview articlepeer-review

1017 Scopus citations

Abstract

Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.

Original languageEnglish
Pages (from-to)269-284
Number of pages16
JournalNature Reviews Microbiology
Volume13
Issue number5
DOIs
StatePublished - May 24 2015

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