TY - JOUR
T1 - Urinary tract infections
T2 - Epidemiology, mechanisms of infection and treatment options
AU - Flores-Mireles, Ana L.
AU - Walker, Jennifer N.
AU - Caparon, Michael
AU - Hultgren, Scott J.
N1 - Funding Information:
The authors apologize to researchers whose work could not be included in this Review owing to space limitations. They thank members of S.J.H.’s and M.G.C.’s laboratories, especially K. W. Dodson, for their suggestions and comments. This work was supported by the 1F32DK104516-01 grant to A.L.F.-M. and the R01-DK051406, R01-AI108749-01 and P50-DK0645400 grants from the US National Institute of Allergy and Infectious Diseases (NIAID) and US National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Publisher Copyright:
© 2015 Macmillan Publishers Limited. All rights reserved.
PY - 2015/5/24
Y1 - 2015/5/24
N2 - Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.
AB - Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.
UR - http://www.scopus.com/inward/record.url?scp=84928414071&partnerID=8YFLogxK
U2 - 10.1038/nrmicro3432
DO - 10.1038/nrmicro3432
M3 - Review article
C2 - 25853778
AN - SCOPUS:84928414071
VL - 13
SP - 269
EP - 284
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 5
ER -