Urinary Tract Infection: Pathogenesis and Outlook

Lisa K. McLellan, David A. Hunstad

Research output: Contribution to journalReview articlepeer-review

106 Scopus citations

Abstract

The clinical syndromes comprising urinary tract infection (UTI) continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial UTI. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental biological investigation. In this review, we highlight contemporary advances in the field of UTI pathogenesis and how these might inform both our clinical perspective and future scientific priorities.

Original languageEnglish
Pages (from-to)946-957
Number of pages12
JournalTrends in Molecular Medicine
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • Escherichia coli
  • cystitis
  • pyelonephritis
  • urinary tract infection

Fingerprint

Dive into the research topics of 'Urinary Tract Infection: Pathogenesis and Outlook'. Together they form a unique fingerprint.

Cite this