Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell disease

Joshua J. Field, Robert C. Strunk, Jessica E. Knight-Perry, Morey A. Blinder, R. Reid Townsend, Michael R. DeBaun

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Baseline level of the cysteinyl leukotriene (CysLT), leukotriene E 4 (LTE4), is associated with an increased pain rate in children and adults with sickle cell disease (SCD). To provide additional evidence for a role of CysLTs in the pathogenesis of vaso-occlusion, we tested the hypothesis that LTE4 levels will increase within an individual during painful episodes compared to baseline. In a cohort of 19 children and adults with SCD, median LTE4 levels increased from 82.36 pg/mg creatinine at baseline to 162.81 pg/mg creatinine during a painful episode (P < 0.001). These data further support a contribution of CysLTs to the process of vaso-occlusion.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalAmerican journal of hematology
Volume84
Issue number4
DOIs
StatePublished - Apr 1 2009

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