Abstract
Baseline level of the cysteinyl leukotriene (CysLT), leukotriene E 4 (LTE4), is associated with an increased pain rate in children and adults with sickle cell disease (SCD). To provide additional evidence for a role of CysLTs in the pathogenesis of vaso-occlusion, we tested the hypothesis that LTE4 levels will increase within an individual during painful episodes compared to baseline. In a cohort of 19 children and adults with SCD, median LTE4 levels increased from 82.36 pg/mg creatinine at baseline to 162.81 pg/mg creatinine during a painful episode (P < 0.001). These data further support a contribution of CysLTs to the process of vaso-occlusion.
Original language | English |
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Pages (from-to) | 231-233 |
Number of pages | 3 |
Journal | American journal of hematology |
Volume | 84 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2009 |