Urinary adenosine 3',5'-monophosphate excretion in normal children and children with type I diabetes mellitus

M. F. Witt; N. H. White; J. V. Santiago; L. V. Avioli

doi:10.1055/s-2007-1014691

Urinary adenosine 3',5'-monophosphate excretion in normal children and children with type I diabetes mellitus

M. F. Witt, N. H. White, J. V. Santiago, L. V. Avioli

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Abstract

We have documented significant elevations in fasting urinary cAMP levels in a homogenous group of young insulin-dependent diabetic subjects. Since cAMP acts as a critical mediator of cellular responses to glucagon and catecholamines (namely glycogenolysis, gluconeogenesis, and lipolysis), its role in diabetes mellitus may be of particular importance. Whether the observed abnormality is related to elevated hormone stimulators or the result of altered cellular responsiveness has not been determined.

Original language	English
Pages (from-to)	50-51
Number of pages	2
Journal	Hormone and Metabolic Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.1055/s-2007-1014691
State	Published - Jan 1 1984

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AB - We have documented significant elevations in fasting urinary cAMP levels in a homogenous group of young insulin-dependent diabetic subjects. Since cAMP acts as a critical mediator of cellular responses to glucagon and catecholamines (namely glycogenolysis, gluconeogenesis, and lipolysis), its role in diabetes mellitus may be of particular importance. Whether the observed abnormality is related to elevated hormone stimulators or the result of altered cellular responsiveness has not been determined.

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Urinary adenosine 3',5'-monophosphate excretion in normal children and children with type I diabetes mellitus

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