TY - JOUR
T1 - UPEC hemolysin
T2 - More than just for making holes
AU - Justice, Sheryl S.
AU - Hunstad, David A.
N1 - Funding Information:
D.A.H. is supported by National Institutes of Health grants R01-DK080752 and R01-DK082546.
PY - 2012/1/19
Y1 - 2012/1/19
N2 - During acute cystitis, uropathogenic Escherichia coli (UPEC) induce bladder epithelial cell exfoliation, which eliminates infected cells and promotes UPEC dissemination. Dhakal and Mulvey (2012) uncover the mechanism that induces this exfoliation and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets multiple host pathways to facilitate infection.
AB - During acute cystitis, uropathogenic Escherichia coli (UPEC) induce bladder epithelial cell exfoliation, which eliminates infected cells and promotes UPEC dissemination. Dhakal and Mulvey (2012) uncover the mechanism that induces this exfoliation and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets multiple host pathways to facilitate infection.
UR - http://www.scopus.com/inward/record.url?scp=84855995839&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2012.01.001
DO - 10.1016/j.chom.2012.01.001
M3 - Short survey
C2 - 22264508
AN - SCOPUS:84855995839
VL - 11
SP - 4
EP - 5
JO - Cell Host and Microbe
JF - Cell Host and Microbe
SN - 1931-3128
IS - 1
ER -