TY - JOUR
T1 - Updated response assessment criteria for high-grade gliomas
T2 - Response assessment in neuro-oncology working group
AU - Wen, Patrick Y.
AU - Macdonald, David R.
AU - Reardon, David A.
AU - Cloughesy, Timothy F.
AU - Sorensen, A. Gregory
AU - Galanis, Evanthia
AU - DeGroot, John
AU - Wick, Wolfgang
AU - Gilbert, Mark R.
AU - Lassman, Andrew B.
AU - Tsien, Christina
AU - Mikkelsen, Tom
AU - Wong, Eric T.
AU - Chamberlain, Marc C.
AU - Stupp, Roger
AU - Lamborn, Kathleen R.
AU - Vogelbaum, Michael A.
AU - Van Den Bent, Martin J.
AU - Chang, Susan M.
PY - 2010/4/10
Y1 - 2010/4/10
N2 - Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or magnetic resonance imaging (MRI), in conjunction with clinical assessment and corticosteroid dose (the Macdonald Criteria). It is increasingly apparent that there are significant limitations to these criteria, which only address the contrast-enhancing component of the tumor. For example, chemoradiotherapy for newly diagnosed glioblastomas results in transient increase in tumor enhancement (pseudoprogression) in 20% to 30% of patients, which is difficult to differentiate from true tumor progression. Antiangiogenic agents produce high radiographic response rates, as defined by a rapid decrease in contrast enhancement on CT/MRI that occurs within days of initiation of treatment and that is partly a result of reduced vascular permeability to contrast agents rather than a true antitumor effect. In addition, a subset of patients treated with antiangiogenic agents develop tumor recurrence characterized by an increase in the nonenhancing component depicted on T2-weighted/fluid-attenuated inversion recovery sequences. The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies. The Response Assessment in Neuro-Oncology Working Group is an international effort to develop new standardized response criteria for clinical trials in brain tumors. In this proposal, we present the recommendations for updated response criteria for high-grade gliomas.
AB - Currently, the most widely used criteria for assessing response to therapy in high-grade gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or magnetic resonance imaging (MRI), in conjunction with clinical assessment and corticosteroid dose (the Macdonald Criteria). It is increasingly apparent that there are significant limitations to these criteria, which only address the contrast-enhancing component of the tumor. For example, chemoradiotherapy for newly diagnosed glioblastomas results in transient increase in tumor enhancement (pseudoprogression) in 20% to 30% of patients, which is difficult to differentiate from true tumor progression. Antiangiogenic agents produce high radiographic response rates, as defined by a rapid decrease in contrast enhancement on CT/MRI that occurs within days of initiation of treatment and that is partly a result of reduced vascular permeability to contrast agents rather than a true antitumor effect. In addition, a subset of patients treated with antiangiogenic agents develop tumor recurrence characterized by an increase in the nonenhancing component depicted on T2-weighted/fluid-attenuated inversion recovery sequences. The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies. The Response Assessment in Neuro-Oncology Working Group is an international effort to develop new standardized response criteria for clinical trials in brain tumors. In this proposal, we present the recommendations for updated response criteria for high-grade gliomas.
UR - http://www.scopus.com/inward/record.url?scp=77951625266&partnerID=8YFLogxK
U2 - 10.1200/JCO.2009.26.3541
DO - 10.1200/JCO.2009.26.3541
M3 - Review article
C2 - 20231676
AN - SCOPUS:77951625266
SN - 0732-183X
VL - 28
SP - 1963
EP - 1972
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 11
ER -