TY - JOUR
T1 - Update on the Management of Acanthamoeba Keratitis
AU - McCoy, Colton
AU - Patel, Shaivi
AU - Thulasi, Praneetha
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/12
Y1 - 2022/12
N2 - Purpose or Review: In this article, we review the latest diagnostic modalities and management of acanthamoeba keratitis Recent Findings: The incidence as well as severity of acanthamoeba keratitis is increasing, making this a challenging disease to treat, especially in patients who have a delay in diagnosis or severe disease at presentation. Newer tools such as voriconazole, miltefosine, and collagen crosslinking may be needed for infection control. Complications such as persistent infection, severe thinning, or perforation may necessitate surgical intervention. Summary: While traditional therapies such as polyhexamethylene biguanide and chlorhexidine remain mainstays of therapy, unresponsive acanthamoeba keratitis may benefit from topical or oral voriconazole, oral miltefosine, or collagen crosslinking. Despite these options, management of these patients remains a challenge.
AB - Purpose or Review: In this article, we review the latest diagnostic modalities and management of acanthamoeba keratitis Recent Findings: The incidence as well as severity of acanthamoeba keratitis is increasing, making this a challenging disease to treat, especially in patients who have a delay in diagnosis or severe disease at presentation. Newer tools such as voriconazole, miltefosine, and collagen crosslinking may be needed for infection control. Complications such as persistent infection, severe thinning, or perforation may necessitate surgical intervention. Summary: While traditional therapies such as polyhexamethylene biguanide and chlorhexidine remain mainstays of therapy, unresponsive acanthamoeba keratitis may benefit from topical or oral voriconazole, oral miltefosine, or collagen crosslinking. Despite these options, management of these patients remains a challenge.
KW - Acanthamoeba
KW - Acanthamoeba keratitis
KW - Collagen crosslinking
KW - Infectious keratitis
KW - Miltefosine
UR - http://www.scopus.com/inward/record.url?scp=85141383132&partnerID=8YFLogxK
U2 - 10.1007/s40135-022-00296-2
DO - 10.1007/s40135-022-00296-2
M3 - Article
AN - SCOPUS:85141383132
SN - 2167-4868
VL - 10
SP - 153
EP - 161
JO - Current Ophthalmology Reports
JF - Current Ophthalmology Reports
IS - 4
ER -