Update on terbinafine with a focus on dermatophytoses

Jason G. Newland, Susan M. Abdel-Rahman

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

Since terbinafine was introduced on the world market 17 years ago, it has become the leading antifungal for the treatment of superficial fungal infections, aided by unique pharmacologic and microbiologic profiles. This article reviews mode of action, antimycotic spectrum and disposition profile of terbinafine. It examines the data, accumulated over 15 years, on the comparative efficacy of terbinafine (vs griseofulvin, itraconazole, fluconazole) in the management of the infections for which it is primarily indicated (eg, dermatophytoses) and provides a brief discussion on its use for the treatment of non-dermatophyte infections. Finally, the available data on the newest topical and systemic formulations are introduced.

Original languageEnglish
Pages (from-to)49-63
Number of pages15
JournalClinical, Cosmetic and Investigational Dermatology
Volume2
StatePublished - 2009

Keywords

  • Allylamine
  • Antifungal
  • Microsporum
  • Tinea
  • Trichophyton

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