TY - JOUR
T1 - Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans
AU - Heiss, Christian
AU - Skowyra, Michael L.
AU - Liu, Hong
AU - Klutts, J. Stacey
AU - Wang, Zhirui
AU - Williams, Matthew
AU - Srikanta, Deepa
AU - Beverley, Stephen M.
AU - Azadi, Parastoo
AU - Doering, Tamara L.
PY - 2013/4/19
Y1 - 2013/4/19
N2 - Background: Galactofuranose, the five-membered ring form of galactose, occurs in the encapsulated pathogenic fungus Cryptococcus neoformans but not in humans. Results: We established the position of galactofuranose within a capsule polysaccharide and characterized cryptococci lacking this modification. Conclusion: Galactofuranose occurs in an unusual linkage but is not required for growth or virulence. Significance: This work fills a gap in knowledge about a pathogen-specific modification.
AB - Background: Galactofuranose, the five-membered ring form of galactose, occurs in the encapsulated pathogenic fungus Cryptococcus neoformans but not in humans. Results: We established the position of galactofuranose within a capsule polysaccharide and characterized cryptococci lacking this modification. Conclusion: Galactofuranose occurs in an unusual linkage but is not required for growth or virulence. Significance: This work fills a gap in knowledge about a pathogen-specific modification.
UR - https://www.scopus.com/pages/publications/84876535850
U2 - 10.1074/jbc.M112.441998
DO - 10.1074/jbc.M112.441998
M3 - Article
C2 - 23408430
AN - SCOPUS:84876535850
SN - 0021-9258
VL - 288
SP - 10994
EP - 11003
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 16
ER -