Unusual galactofuranose modification of a capsule polysaccharide in the pathogenic yeast Cryptococcus neoformans

Christian Heiss, Michael L. Skowyra, Hong Liu, J. Stacey Klutts, Zhirui Wang, Matthew Williams, Deepa Srikanta, Stephen M. Beverley, Parastoo Azadi, Tamara L. Doering

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Galactofuranose, the five-membered ring form of galactose, occurs in the encapsulated pathogenic fungus Cryptococcus neoformans but not in humans. Results: We established the position of galactofuranose within a capsule polysaccharide and characterized cryptococci lacking this modification. Conclusion: Galactofuranose occurs in an unusual linkage but is not required for growth or virulence. Significance: This work fills a gap in knowledge about a pathogen-specific modification.

Original languageEnglish
Pages (from-to)10994-11003
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number16
DOIs
StatePublished - Apr 19 2013

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