Unravelling the ties that bind: The intersection of obesity, osteoarthritis, and inflammatory pathways with emphasis on glucagon-like peptide-1 agonists

Naadir Jamal, William Hollabaugh, Leon Scott, Sahar Takkouche

Research output: Contribution to journalReview articlepeer-review

Abstract

This narrative review article explores the complex interplay between obesity, osteoarthritis, and their associated inflammatory cascades, offering a deeper understanding of the underlying of mechanisms of inflammation and potential therapeutic interventions targeting both diseases. Through examination of the shared inflammatory pathway of obesity and osteoarthritis, our objective is to directly elucidate the relationship between these two conditions, highlighting the promising role of glucagon-like peptide-1 agonists in modulating inflammation and its therapeutic implications for patients with obesity and osteoarthritis.

Original languageEnglish
Article numbere12700
JournalClinical Obesity
Volume15
Issue number1
DOIs
StateAccepted/In press - 2024

Keywords

  • glucagon-like peptide-1 receptor agonist
  • glucose-dependent insulinotropic polypeptide
  • inflammatory pathways
  • liraglutide
  • obesity
  • osteoarthritis

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