TY - JOUR
T1 - Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension
T2 - implications for clinical research and its therapeutic approach
AU - Mitra, Ankita
AU - Yi, Dan
AU - Dai, Zhiyu
AU - de Jesus Perez, Vinicio
N1 - Publisher Copyright:
Copyright © 2024 Mitra, Yi, Dai and de Jesus Perez.
PY - 2024
Y1 - 2024
N2 - Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling with high pulmonary pressure, which ultimately leads to right heart failure and premature death. Emerging evidence suggests that both hypoxia and epigenetics play a pivotal role in the pathogenesis of PAH development. In this review article, we summarize the current developments in regulation of hypoxia inducible factor (HIF) isoforms in PAH vascular remodeling and the development of suitable animal models for discovery and testing of HIF pathway-targeting PAH therapeutics. In addition, we also discuss the epigenetic regulation of HIF-dependent isoforms in PAH and its therapeutic potential from a new perspective which highlights the importance of HIF isoform-specific targeting as a novel salutary strategy for PAH treatment.
AB - Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling with high pulmonary pressure, which ultimately leads to right heart failure and premature death. Emerging evidence suggests that both hypoxia and epigenetics play a pivotal role in the pathogenesis of PAH development. In this review article, we summarize the current developments in regulation of hypoxia inducible factor (HIF) isoforms in PAH vascular remodeling and the development of suitable animal models for discovery and testing of HIF pathway-targeting PAH therapeutics. In addition, we also discuss the epigenetic regulation of HIF-dependent isoforms in PAH and its therapeutic potential from a new perspective which highlights the importance of HIF isoform-specific targeting as a novel salutary strategy for PAH treatment.
KW - animal model
KW - epigenetics
KW - hypoxia inducible factor
KW - pulmonary arterial hypertension
KW - therapeutics
UR - http://www.scopus.com/inward/record.url?scp=85207236934&partnerID=8YFLogxK
U2 - 10.3389/fmed.2024.1460376
DO - 10.3389/fmed.2024.1460376
M3 - Review article
C2 - 39450110
AN - SCOPUS:85207236934
SN - 2296-858X
VL - 11
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 1460376
ER -