TY - JOUR
T1 - Unraveling the origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites. A DNA synthesis building block for the cis-syn cyclobutane dimer of dTpdU.
AU - Taylor, John Stephen
AU - Nadji, Sourena
N1 - Funding Information:
by a grant from the Natkmal lnetkutescf Health (RRW954), and the MkfweetC enter for Mace Spectrometry,a National
PY - 1991
Y1 - 1991
N2 - One possible origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites, involves the replicative bypass of the cyclobutane dimer of dTpdC or its deamination product, the cis-syn dimer of dTpdU. In order to investigate the latter proposal, we have designed and synthesized a building block for the incorporation of the cis-syn dTpdU dimer into oligonucleotides by automated solid phase DNA synthesis technology.
AB - One possible origin of the major mutation induced by ultraviolet light, the C→T transition at dTpdC sites, involves the replicative bypass of the cyclobutane dimer of dTpdC or its deamination product, the cis-syn dimer of dTpdU. In order to investigate the latter proposal, we have designed and synthesized a building block for the incorporation of the cis-syn dTpdU dimer into oligonucleotides by automated solid phase DNA synthesis technology.
UR - http://www.scopus.com/inward/record.url?scp=0026093232&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(01)81791-9
DO - 10.1016/S0040-4020(01)81791-9
M3 - Article
AN - SCOPUS:0026093232
SN - 0040-4020
VL - 47
SP - 2579
EP - 2590
JO - Tetrahedron
JF - Tetrahedron
IS - 14-15
ER -