Abstract

Aoki and colleagues have utilized single-cell RNA sequencing and imaging mass cytometry to describe the landscape of reactive, nonmalignant immune-cell populations present in classic Hodgkin lymphoma (cHL), and delineate their spatial proximity to malignant Hodgkin–Reed–Sternberg cells. From this study, they have identified a LAG3-expressing Tr1-type Treg cell population as prevalent mainly in MHC-II–negative cHL, implying a potential functional relationship underlying the differential responsiveness of MHC-II–negative versus MHC-II– positive cHLs to immunotherapy.

Original languageEnglish
Pages (from-to)342-344
Number of pages3
JournalCancer discovery
Volume10
Issue number3
DOIs
StatePublished - Mar 2020

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