Unlocking the secrets to regenerating cardiac tissue: an update

Olga N. Kislitsina, Amiran S. Revishvili, James L. Cox

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The use of extracellular matrix has evolved into a promising therapeutic approach for the treatment of valve disease and heart failure. Both biomechanical and biochemical signals for tissue remodelling require the presence of the extracellular matrix to recognize the remodelling signals and transfer them to the host stem cells. The extracellular matrix is the key to delivering these signals to the immigrated stem cells, and it also serves as a 'stem cell scaffold' making the possibility of regenerating new cardiac tissue a reality.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalInteractive cardiovascular and thoracic surgery
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Extracellular matrix
  • Heart failure
  • Heart valves
  • Regeneration
  • Remodelling
  • Stem cells

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