Unique technical challenges in patients undergoing TAVR for failed aortic homografts

Olga N. Kislitsina, Michal Szlapka, Patrick M. McCarthy, Charles J. Davidson, James D. Flaherty, Ranya N. Sweis, Jane Kruse, Adin C. Andrei, James L. Cox, S. Christopher Malaisrie

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objective: Surgical reoperation for aortic homograft structural valve degeneration (SVD) is a high-risk procedure. Transcatheter aortic valve replacement (TAVR) for homograft-SVD is an alternative to reoperation, but descriptions of implantation techniques are limited. This study compares outcome in patients undergoing into two groups by the type of previously implanted aortic valve prosthesis: TAVR for failed aortic homografts (TAVR-H) or for stented aortic bioprostheses (TAVR-BP). Methods: From 2015 to 2017, TAVR was performed in 41 patients with SVD. Thirty-three patients in the TAVR-BP group (six for SVD of valved conduits), and eight patients in the TAVR-H group. The Valve Academic Research Consortium criteria were used for outcome reporting purposes. Results: The patients with TAVR-BP had predominant prosthetic stenosis (94%, p =.002), whereas TAVR-H individuals presented mostly with regurgitation (88%, p = <.001). Patients with TAVR-H received: Sapien-3 (6), Sapien-XT (1), and CoreValve (1) devices. Low, 40% ventricular fixation in relation to homograft annulus was attempted to anchor the prosthesis on the homograft suture-line. One patient with TAVR-BP experienced intraoperative distal prosthesis migration and Type-B aortic dissection, and two patients in the TAVR-H group had late postoperative proximal device migration. In both groups, there was zero 30-day mortality, stroke, or pacemaker implantation. Conclusions: TAVR for failing aortic homografts may be a feasible and safe alternative to high-risk surgical reintervention. Precise, 40%-ventricular device positioning appears crucial for prevention of late paravalvular leak/late prosthesis migration and minimizing the risk of repeat surgical intervention.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalJournal of cardiac surgery
Issue number1
StatePublished - Jan 2021


  • TAVR
  • aortic bioprostheses
  • homograft


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