Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings

Francis X. Witkoski; Patricia A. Penkoske; Katherine M. Kavanagh

Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings

Francis X. Witkoski, Patricia A. Penkoske, Katherine M. Kavanagh

Division of Critical Care

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The correct interpretation of extracellular electrical recording from cardiac muscle is critically dependent on the criteria employed to distinguish propagated electrical activity from electrotonic interactions. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. Combining this with an immediately adjacent fiberoptically coupled transmembrane potential recording array, electrotonic deflections during ventricular fibrillation were examined. Using these arrays in isolated blood perfused dog hearts, all electrotonic deflections were characterized by a transmembrane current that lacked any inwardly directed component.

Original language	English
Title of host publication	Proceedings of the Annual Conference on Engineering in Medicine and Biology
Editors	Andrew Y.J. Szeto, Rangaraj M. Rangayyan
Publisher	Publ by IEEE
Pages	859-860
Number of pages	2
Edition	pt 2
ISBN (Print)	0780313771
State	Published - Dec 1 1993
Event	Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3) - San Diego, CA, USA Duration: Oct 28 1993 → Oct 31 1993

Publication series

Name	Proceedings of the Annual Conference on Engineering in Medicine and Biology
Number	pt 2
Volume	15
ISSN (Print)	0589-1019

Conference

Conference	Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3)
City	San Diego, CA, USA
Period	10/28/93 → 10/31/93

Cite this

Witkoski, F. X., Penkoske, P. A., & Kavanagh, K. M. (1993). Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings. In A. Y. J. Szeto, & R. M. Rangayyan (Eds.), Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., pp. 859-860). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; Vol. 15, No. pt 2). Publ by IEEE.

Witkoski, Francis X. ; Penkoske, Patricia A. ; Kavanagh, Katherine M. / Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings. Proceedings of the Annual Conference on Engineering in Medicine and Biology. editor / Andrew Y.J. Szeto ; Rangaraj M. Rangayyan. pt 2. ed. Publ by IEEE, 1993. pp. 859-860 (Proceedings of the Annual Conference on Engineering in Medicine and Biology; pt 2).

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title = "Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings",

abstract = "The correct interpretation of extracellular electrical recording from cardiac muscle is critically dependent on the criteria employed to distinguish propagated electrical activity from electrotonic interactions. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. Combining this with an immediately adjacent fiberoptically coupled transmembrane potential recording array, electrotonic deflections during ventricular fibrillation were examined. Using these arrays in isolated blood perfused dog hearts, all electrotonic deflections were characterized by a transmembrane current that lacked any inwardly directed component.",

author = "Witkoski, {Francis X.} and Penkoske, {Patricia A.} and Kavanagh, {Katherine M.}",

year = "1993",

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booktitle = "Proceedings of the Annual Conference on Engineering in Medicine and Biology",

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note = "Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3) ; Conference date: 28-10-1993 Through 31-10-1993",

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Witkoski, FX, Penkoske, PA & Kavanagh, KM 1993, Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings. in AYJ Szeto & RM Rangayyan (eds), Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 edn, Proceedings of the Annual Conference on Engineering in Medicine and Biology, no. pt 2, vol. 15, Publ by IEEE, pp. 859-860, Proceedings of the 15th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 2 (of 3), San Diego, CA, USA, 10/28/93.

Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings. / Witkoski, Francis X.; Penkoske, Patricia A.; Kavanagh, Katherine M.
Proceedings of the Annual Conference on Engineering in Medicine and Biology. ed. / Andrew Y.J. Szeto; Rangaraj M. Rangayyan. pt 2. ed. Publ by IEEE, 1993. p. 859-860 (Proceedings of the Annual Conference on Engineering in Medicine and Biology; Vol. 15, No. pt 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Kavanagh, Katherine M.

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N2 - The correct interpretation of extracellular electrical recording from cardiac muscle is critically dependent on the criteria employed to distinguish propagated electrical activity from electrotonic interactions. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. Combining this with an immediately adjacent fiberoptically coupled transmembrane potential recording array, electrotonic deflections during ventricular fibrillation were examined. Using these arrays in isolated blood perfused dog hearts, all electrotonic deflections were characterized by a transmembrane current that lacked any inwardly directed component.

AB - The correct interpretation of extracellular electrical recording from cardiac muscle is critically dependent on the criteria employed to distinguish propagated electrical activity from electrotonic interactions. We have recently developed a technique utilizing microscopically dimensioned extracellular recording electrode arrays for estimating the cardiac transmembrane current that crosses the myocardial membrane during cardiac activation. Combining this with an immediately adjacent fiberoptically coupled transmembrane potential recording array, electrotonic deflections during ventricular fibrillation were examined. Using these arrays in isolated blood perfused dog hearts, all electrotonic deflections were characterized by a transmembrane current that lacked any inwardly directed component.

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BT - Proceedings of the Annual Conference on Engineering in Medicine and Biology

A2 - Szeto, Andrew Y.J.

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Witkoski FX, Penkoske PA, Kavanagh KM. Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings. In Szeto AYJ, Rangayyan RM, editors, Proceedings of the Annual Conference on Engineering in Medicine and Biology. pt 2 ed. Publ by IEEE. 1993. p. 859-860. (Proceedings of the Annual Conference on Engineering in Medicine and Biology; pt 2).

Unique signature of cardiac electrotonic deflections demonstrated by transmembrane recordings

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