Unique pulmonary antigen presentation may call for an alternative approach for lung cancer immunotherapy

Stephanie Chang; Xue Lin; Ryuji Higashikubo; Kelsey Toth; Andrew E. Gelman; Daniel Kreisel; Alexander S. Krupnick

doi:10.4161/onci.23563

Unique pulmonary antigen presentation may call for an alternative approach for lung cancer immunotherapy

Stephanie Chang, Xue Lin, Ryuji Higashikubo, Kelsey Toth, Andrew E. Gelman, Daniel Kreisel, Alexander S. Krupnick

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5 Scopus citations

Abstract

Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.

Original language	English
Article number	e23563
Journal	OncoImmunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/onci.23563
State	Published - Mar 2013

Keywords

Adoptive immune system
Immunotherapy
Lung cancer
Mucosal antigen presentation
Natural killer cells

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10.4161/onci.23563

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title = "Unique pulmonary antigen presentation may call for an alternative approach for lung cancer immunotherapy",

abstract = "Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.",

keywords = "Adoptive immune system, Immunotherapy, Lung cancer, Mucosal antigen presentation, Natural killer cells",

author = "Stephanie Chang and Xue Lin and Ryuji Higashikubo and Kelsey Toth and Gelman, {Andrew E.} and Daniel Kreisel and Krupnick, {Alexander S.}",

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AU - Gelman, Andrew E.

AU - Kreisel, Daniel

AU - Krupnick, Alexander S.

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AB - Unlike other tumors, lung cancer appears to be poorly sensitive to immunotherapy. We have recently demonstrated an alternative pathway of lung cancer immunosurveillance. Our data indicate a failure of the adaptive immune system to mediate the immunosurveillance of lung cancer and emphasize the prominent role of natural killer cells in this setting.

KW - Adoptive immune system

KW - Immunotherapy

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KW - Mucosal antigen presentation

KW - Natural killer cells

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Unique pulmonary antigen presentation may call for an alternative approach for lung cancer immunotherapy

Abstract

Keywords

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