TY - GEN
T1 - Unique personalities within the NF-κB family
T2 - Distinct functions for p65 and relB in the osteoclast
AU - Novack, Deborah Veis
PY - 2011
Y1 - 2011
N2 - The osteoclast (OC) is the resorptive cell of the skeleton responsible for both normal homeostasis and pathological bone loss. NF-κB is a critical signal for OC differentiation downstream of RANKL, and its global disruption protects mice from pathological bone loss. Differently from other TNF family members, RANKL activates both the classical NF-κB pathway, activating both p65 and cRel, and the alternative pathway, inducing expression and activation of RelB. In order to determine whether the classical and alternative NF-κB pathways have distinct roles in OC differentiation, we examined mice lacking p65, RelB, or cRel.
AB - The osteoclast (OC) is the resorptive cell of the skeleton responsible for both normal homeostasis and pathological bone loss. NF-κB is a critical signal for OC differentiation downstream of RANKL, and its global disruption protects mice from pathological bone loss. Differently from other TNF family members, RANKL activates both the classical NF-κB pathway, activating both p65 and cRel, and the alternative pathway, inducing expression and activation of RelB. In order to determine whether the classical and alternative NF-κB pathways have distinct roles in OC differentiation, we examined mice lacking p65, RelB, or cRel.
UR - http://www.scopus.com/inward/record.url?scp=79954426841&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-6612-4_17
DO - 10.1007/978-1-4419-6612-4_17
M3 - Conference contribution
C2 - 21153320
AN - SCOPUS:79954426841
SN - 9781441966117
T3 - Advances in Experimental Medicine and Biology
SP - 163
EP - 167
BT - Advances in TNF Family Research
A2 - Wallach, David
A2 - Kovalenko, Andrew
A2 - Feldmann, Marc
ER -