TY - JOUR
T1 - Unique aspects of transcriptional regulation in neurons - Nuances in NFκB and Sp1-related factors
AU - Mao, Xianrong R.
AU - Moerman-Herzog, Andréa M.
AU - Chen, Yuzhi
AU - Barger, Steven W.
N1 - Funding Information:
This work was supported by funds from the NIH (R01NS046439 and P01AG12411). The κB-βgal transgenic mice were a gift from Philip A. Barker (McGill Univ., Montreal). βAPP-knockout and corresponding wildtype mice were gifts from Hui Zheng (Baylor College of Medicine, Houston).
PY - 2009/5/18
Y1 - 2009/5/18
N2 - The unique physiology and function of neurons create differences in their cellular physiology, including their regulation of gene expression. We began several years ago exploring the relationships between the NFκB transcription factor, neuronal survival, and glutamate receptor activation in telencephalic neurons. These studies led us to conclude that this population of cells is nearly incapable of activating the NFκB that is nonetheless expressed at reasonable levels. A subset of the κB cis elements are instead bound by members of the Sp1 family in neurons. Also surprising was our discovery that Sp1 itself, typically described as ubiquitous, is severely restricted in expression within forebrain neurons; Sp4 seems to be substituted during neuronal differentiation. These findings and their implications for neuronal differentiation - as well as potential dedifferentiation during degenerative processes - are discussed here.
AB - The unique physiology and function of neurons create differences in their cellular physiology, including their regulation of gene expression. We began several years ago exploring the relationships between the NFκB transcription factor, neuronal survival, and glutamate receptor activation in telencephalic neurons. These studies led us to conclude that this population of cells is nearly incapable of activating the NFκB that is nonetheless expressed at reasonable levels. A subset of the κB cis elements are instead bound by members of the Sp1 family in neurons. Also surprising was our discovery that Sp1 itself, typically described as ubiquitous, is severely restricted in expression within forebrain neurons; Sp4 seems to be substituted during neuronal differentiation. These findings and their implications for neuronal differentiation - as well as potential dedifferentiation during degenerative processes - are discussed here.
UR - http://www.scopus.com/inward/record.url?scp=67649745938&partnerID=8YFLogxK
U2 - 10.1186/1742-2094-6-16
DO - 10.1186/1742-2094-6-16
M3 - Review article
C2 - 19450264
AN - SCOPUS:67649745938
SN - 1742-2094
VL - 6
JO - Journal of Neuroinflammation
JF - Journal of Neuroinflammation
M1 - 16
ER -