Unique aspects of transcriptional regulation in neurons - Nuances in NFκB and Sp1-related factors

Xianrong R. Mao, Andréa M. Moerman-Herzog, Yuzhi Chen, Steven W. Barger

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations

Abstract

The unique physiology and function of neurons create differences in their cellular physiology, including their regulation of gene expression. We began several years ago exploring the relationships between the NFκB transcription factor, neuronal survival, and glutamate receptor activation in telencephalic neurons. These studies led us to conclude that this population of cells is nearly incapable of activating the NFκB that is nonetheless expressed at reasonable levels. A subset of the κB cis elements are instead bound by members of the Sp1 family in neurons. Also surprising was our discovery that Sp1 itself, typically described as ubiquitous, is severely restricted in expression within forebrain neurons; Sp4 seems to be substituted during neuronal differentiation. These findings and their implications for neuronal differentiation - as well as potential dedifferentiation during degenerative processes - are discussed here.

Original languageEnglish
Article number16
JournalJournal of Neuroinflammation
Volume6
DOIs
StatePublished - May 18 2009

Fingerprint Dive into the research topics of 'Unique aspects of transcriptional regulation in neurons - Nuances in NFκB and Sp1-related factors'. Together they form a unique fingerprint.

Cite this