Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

Stephen L. Lee, Robin L. Wesselschmidt, Gerald P. Linette, Osami Kanagawa, John H. Russell, Jeffrey Milbrandt

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4+ peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death.

Original languageEnglish
Pages (from-to)532-535
Number of pages4
JournalScience
Volume269
Issue number5223
DOIs
StatePublished - 1995

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