TY - JOUR
T1 - Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease
AU - Farooq, Asim V.
AU - Paley, Grace L.
AU - Lubniewski, Anthony J.
AU - Gonzales, John A.
AU - Margolis, Todd P.
N1 - Funding Information:
Supported in part by an unrestricted grant from Research To Prevent Blindness to the Department of Ophthalmology and Visual Sciences at Washington University. The funding organization had no role in the design or conduct of this research.
Publisher Copyright:
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose: To describe a case series of patients with unilateral, posterior interstitial keratitis presumed to be caused by herpes simplex virus. Methods: Retrospective case series. Results: Five patients were found to have unilateral, posterior interstitial keratitis. Three of the involved eyes had decreased corneal sensation, and 2 eyes had corneal stromal neovascularization. All patients were treated with topical steroids and an oral antiviral, and among those with long-term follow-up, clinical improvement required treatment over an extended duration. A review of the literature revealed 1 reported case with a similar clinical appearance, although that case was attributed to Lyme disease. Conclusions: The clinical presentation of unilateral, posterior interstitial keratitis may be a rare manifestation of herpes simplex virus keratitis.
AB - Purpose: To describe a case series of patients with unilateral, posterior interstitial keratitis presumed to be caused by herpes simplex virus. Methods: Retrospective case series. Results: Five patients were found to have unilateral, posterior interstitial keratitis. Three of the involved eyes had decreased corneal sensation, and 2 eyes had corneal stromal neovascularization. All patients were treated with topical steroids and an oral antiviral, and among those with long-term follow-up, clinical improvement required treatment over an extended duration. A review of the literature revealed 1 reported case with a similar clinical appearance, although that case was attributed to Lyme disease. Conclusions: The clinical presentation of unilateral, posterior interstitial keratitis may be a rare manifestation of herpes simplex virus keratitis.
KW - herpes simplex virus
KW - interstitial keratitis
KW - neurotrophic keratitis
KW - posterior stromal keratitis
KW - stromal keratitis
UR - http://www.scopus.com/inward/record.url?scp=85045544204&partnerID=8YFLogxK
U2 - 10.1097/ICO.0000000000001499
DO - 10.1097/ICO.0000000000001499
M3 - Article
C2 - 29256984
AN - SCOPUS:85045544204
SN - 0277-3740
VL - 37
SP - 375
EP - 378
JO - Cornea
JF - Cornea
IS - 3
ER -