TY - JOUR
T1 - Unifying concepts of MHC-dependent natural killer cell education
AU - Elliott, Julie M.
AU - Yokoyama, Wayne M.
N1 - Funding Information:
The authors thank members of the Yokoyama laboratory who have contributed to understanding NK cell function and differentiation over the years. Work in the Yokoyama laboratory is supported by grants from the NIH (AI33903, AI51345, AI57160) and the Howard Hughes Medical Institute.
PY - 2011/8
Y1 - 2011/8
N2 - Natural killer (NK) cells, like B and T lymphocytes, are potent effector cells that are crucial for immunity to tumors and infections. These effector responses must be controlled to avoid inadvertent attack against normal self. Yet, the mechanisms that guide NK cell tolerance differ from those guiding T and B cell tolerance. Here, we discuss how NK cells are licensed by self-MHC class I molecules through their inhibitory receptors which results in NK cell functional competence to be triggered through their activation receptors. We discuss recent data with respect to issues related to licensing, thereby providing a framework for unifying concepts on NK cell education.
AB - Natural killer (NK) cells, like B and T lymphocytes, are potent effector cells that are crucial for immunity to tumors and infections. These effector responses must be controlled to avoid inadvertent attack against normal self. Yet, the mechanisms that guide NK cell tolerance differ from those guiding T and B cell tolerance. Here, we discuss how NK cells are licensed by self-MHC class I molecules through their inhibitory receptors which results in NK cell functional competence to be triggered through their activation receptors. We discuss recent data with respect to issues related to licensing, thereby providing a framework for unifying concepts on NK cell education.
UR - http://www.scopus.com/inward/record.url?scp=79960914933&partnerID=8YFLogxK
U2 - 10.1016/j.it.2011.06.001
DO - 10.1016/j.it.2011.06.001
M3 - Review article
C2 - 21752715
AN - SCOPUS:79960914933
SN - 1471-4906
VL - 32
SP - 364
EP - 372
JO - Trends in Immunology
JF - Trends in Immunology
IS - 8
ER -