Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients

Mushal Noor; Philip J. Katzman; Aaron R. Huber; Jennifer J. Findeis-Hosey; Christa Whitney-Miller; Raul S. Gonzalez; Zhongren Zhou; Henriette D. N'Kodia; Kathryn Skonick; Rebecca L. Abell; Lawrence J. Saubermann; Laura W. Lamps; Michael G. Drage

doi:10.1093/ajcp/aqy122

Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients

Mushal Noor, Philip J. Katzman, Aaron R. Huber, Jennifer J. Findeis-Hosey, Christa Whitney-Miller, Raul S. Gonzalez, Zhongren Zhou, Henriette D. N'Kodia, Kathryn Skonick, Rebecca L. Abell, Lawrence J. Saubermann, Laura W. Lamps, Michael G. Drage

Division of Anatomic and Molecular Pathology (AMP)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Indications for cholecystectomy have changed dramatically over the past three decades. Cystoisospora belli has been reported in cholecystectomy specimens of immunocompetent patients. The present study was designed to determine the prevalence and clinical association of C belli in the gallbladder. Methods: The study included retrospective review of cholecystectomy specimens (n = 401) removed for various indications, and a prospective cohort of cholecystectomy specimens (n = 22) entirely submitted for histologic evaluation. Correlations of presence of C belli with age, sex, clinical indication, and abnormalities of preoperative laboratory values were assessed by Fisher exact test. Results: C belli was identified in 39/401 (9.7%) of the retrospective cohort, and 6/22 (27.3%) of the entirely submitted specimens. The presence of C belli showed no correlation with age, sex, clinical indication, or laboratory abnormalities.

Original language	English
Pages (from-to)	100-107
Number of pages	8
Journal	American journal of clinical pathology
Volume	151
Issue number	1
DOIs	https://doi.org/10.1093/ajcp/aqy122
State	Published - Jan 1 2019

Keywords

Cholecystectomy
Cystoisospora belli
Gallbladder

Access to Document

10.1093/ajcp/aqy122

Cite this

Noor, M., Katzman, P. J., Huber, A. R., Findeis-Hosey, J. J., Whitney-Miller, C., Gonzalez, R. S., Zhou, Z., N'Kodia, H. D., Skonick, K., Abell, R. L., Saubermann, L. J., Lamps, L. W., & Drage, M. G. (2019). Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients. American journal of clinical pathology, 151(1), 100-107. https://doi.org/10.1093/ajcp/aqy122

@article{1716ad8d03c942ef9ea559db8a59a3bd,

title = "Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients",

abstract = "Indications for cholecystectomy have changed dramatically over the past three decades. Cystoisospora belli has been reported in cholecystectomy specimens of immunocompetent patients. The present study was designed to determine the prevalence and clinical association of C belli in the gallbladder. Methods: The study included retrospective review of cholecystectomy specimens (n = 401) removed for various indications, and a prospective cohort of cholecystectomy specimens (n = 22) entirely submitted for histologic evaluation. Correlations of presence of C belli with age, sex, clinical indication, and abnormalities of preoperative laboratory values were assessed by Fisher exact test. Results: C belli was identified in 39/401 (9.7%) of the retrospective cohort, and 6/22 (27.3%) of the entirely submitted specimens. The presence of C belli showed no correlation with age, sex, clinical indication, or laboratory abnormalities.",

keywords = "Cholecystectomy, Cystoisospora belli, Gallbladder",

author = "Mushal Noor and Katzman, {Philip J.} and Huber, {Aaron R.} and Findeis-Hosey, {Jennifer J.} and Christa Whitney-Miller and Gonzalez, {Raul S.} and Zhongren Zhou and N'Kodia, {Henriette D.} and Kathryn Skonick and Abell, {Rebecca L.} and Saubermann, {Lawrence J.} and Lamps, {Laura W.} and Drage, {Michael G.}",

year = "2019",

month = jan,

day = "1",

doi = "10.1093/ajcp/aqy122",

language = "English",

volume = "151",

pages = "100--107",

journal = "American Journal of Clinical Pathology",

issn = "0002-9173",

number = "1",

}

Noor, M, Katzman, PJ, Huber, AR, Findeis-Hosey, JJ, Whitney-Miller, C, Gonzalez, RS, Zhou, Z, N'Kodia, HD, Skonick, K, Abell, RL, Saubermann, LJ, Lamps, LW & Drage, MG 2019, 'Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients', American journal of clinical pathology, vol. 151, no. 1, pp. 100-107. https://doi.org/10.1093/ajcp/aqy122

TY - JOUR

T1 - Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients

AU - Noor, Mushal

AU - Katzman, Philip J.

AU - Huber, Aaron R.

AU - Findeis-Hosey, Jennifer J.

AU - Whitney-Miller, Christa

AU - Gonzalez, Raul S.

AU - Zhou, Zhongren

AU - N'Kodia, Henriette D.

AU - Skonick, Kathryn

AU - Abell, Rebecca L.

AU - Saubermann, Lawrence J.

AU - Lamps, Laura W.

AU - Drage, Michael G.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Indications for cholecystectomy have changed dramatically over the past three decades. Cystoisospora belli has been reported in cholecystectomy specimens of immunocompetent patients. The present study was designed to determine the prevalence and clinical association of C belli in the gallbladder. Methods: The study included retrospective review of cholecystectomy specimens (n = 401) removed for various indications, and a prospective cohort of cholecystectomy specimens (n = 22) entirely submitted for histologic evaluation. Correlations of presence of C belli with age, sex, clinical indication, and abnormalities of preoperative laboratory values were assessed by Fisher exact test. Results: C belli was identified in 39/401 (9.7%) of the retrospective cohort, and 6/22 (27.3%) of the entirely submitted specimens. The presence of C belli showed no correlation with age, sex, clinical indication, or laboratory abnormalities.

AB - Indications for cholecystectomy have changed dramatically over the past three decades. Cystoisospora belli has been reported in cholecystectomy specimens of immunocompetent patients. The present study was designed to determine the prevalence and clinical association of C belli in the gallbladder. Methods: The study included retrospective review of cholecystectomy specimens (n = 401) removed for various indications, and a prospective cohort of cholecystectomy specimens (n = 22) entirely submitted for histologic evaluation. Correlations of presence of C belli with age, sex, clinical indication, and abnormalities of preoperative laboratory values were assessed by Fisher exact test. Results: C belli was identified in 39/401 (9.7%) of the retrospective cohort, and 6/22 (27.3%) of the entirely submitted specimens. The presence of C belli showed no correlation with age, sex, clinical indication, or laboratory abnormalities.

KW - Cholecystectomy

KW - Cystoisospora belli

KW - Gallbladder

UR - http://www.scopus.com/inward/record.url?scp=85058467539&partnerID=8YFLogxK

U2 - 10.1093/ajcp/aqy122

DO - 10.1093/ajcp/aqy122

M3 - Article

C2 - 30285068

AN - SCOPUS:85058467539

SN - 0002-9173

VL - 151

SP - 100

EP - 107

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

IS - 1

ER -

Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this