Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons

Edgar Turner Overton; Somnuek Sungkanuparph; William G. Powderly; Warren Seyfried; Richard K. Groger; Judith A. Aberg

doi:10.1086/433180

Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons

Edgar Turner Overton
, Somnuek Sungkanuparph
, William G. Powderly
, Warren Seyfried
, Richard K. Groger
, Judith A. Aberg

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Human immunodeficiency virus (HIV)-infected patients respond poorly to hepatitis B vaccination. Records of 194 HIV-infected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P = .003).

Original language	English
Pages (from-to)	1045-1048
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	41
Issue number	7
DOIs	https://doi.org/10.1086/433180
State	Published - Oct 1 2005

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title = "Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons",

abstract = "Human immunodeficiency virus (HIV)-infected patients respond poorly to hepatitis B vaccination. Records of 194 HIV-infected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5\%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P = .003).",

author = "Overton, \{Edgar Turner\} and Somnuek Sungkanuparph and Powderly, \{William G.\} and Warren Seyfried and Groger, \{Richard K.\} and Aberg, \{Judith A.\}",

note = "Funding Information: Financial support. Adult AIDS Clinical Trials Group, funded by the National Institute of Allergy and Infectious Diseases (AI-38858, AI-25903, and AI-27665). Potential conflicts of interest. All authors: no conflicts.",

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AU - Sungkanuparph, Somnuek

AU - Powderly, William G.

AU - Seyfried, Warren

AU - Groger, Richard K.

AU - Aberg, Judith A.

N1 - Funding Information: Financial support. Adult AIDS Clinical Trials Group, funded by the National Institute of Allergy and Infectious Diseases (AI-38858, AI-25903, and AI-27665). Potential conflicts of interest. All authors: no conflicts.

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N2 - Human immunodeficiency virus (HIV)-infected patients respond poorly to hepatitis B vaccination. Records of 194 HIV-infected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P = .003).

AB - Human immunodeficiency virus (HIV)-infected patients respond poorly to hepatitis B vaccination. Records of 194 HIV-infected patients were reviewed for factors associated with successful hepatitis B vaccination. Thirty-four patients (17.5%) developed a protective antibody response. In a logistic regression model, only a plasma HIV RNA level of <400 copies/mL at the time of vaccination was associated with a protective antibody response (P = .003).

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Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons

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